1. Membrane Transporter/Ion Channel
  2. CFTR
  3. Galicaftor

Galicaftor (Synonyms: ABBV-2222; GLPG-2222)

Cat. No.: HY-111111
Handling Instructions

Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research.

For research use only. We do not sell to patients.

Galicaftor Chemical Structure

Galicaftor Chemical Structure

CAS No. : 1918143-53-9

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Description

Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research[1].

In Vitro

Galicaftor (ABBV-2222; GLPG-2222) exhibits potent in vitro functional activity in primary patient cells harboring F508del/F508del CFTR, with an EC50 <10 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The rat pharmacokinetic tests are performed on Galicaftor (ABBV-2222; GLPG-2222; 1 mg/kg, i.v.; 1 mg/kg, p.o.) to illustrate its pharmacokinetic properties in rats. The T1/2 is 2.7 hours (i.v.). And for intragastric administration, the bioavailability (%F) is 74%[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

559.46

Formula

C₂₈H₂₁F₄NO₇

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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