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Cat. No.: HY-111111R

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Galicaftor (Standard)

Name: Galicaftor (Standard)
Brand: MedChemExpress
SKU: HY-111111R
Availability: PreOrder

(Synonyms: ABBV-2222 (Standard); GLPG-2222 (Standard))

Galicaftor (Standard) is the analytical standard of Galicaftor (HY-111111). This product is intended for research and analytical applications. Galicaftor (ABBV-2222; GLPG-2222) is a potent and orally active cystic fibrosis transmembrane conductance regulator (CFTR) corrector. Galicaftor can be used for cystic fibrosis research.

For research use only. We do not sell to patients.

CAS No.: 1918143-53-9
Formula: C₂₈H₂₁F₄NO₇
Molecular Weight:559.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Galicaftor (Standard) Chemical Structure

CAS No.: 1918143-53-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 1918143-53-9
Molecular Weight 559.46
Formula C₂₈H₂₁F₄NO₇
SMILES

O=C(O)C1=CC=C([C@H]2C[C@@H](NC(C3(C4=CC=C(OC(F)(F)O5)C5=C4)CC3)=O)C6=CC=C(OC(F)F)C=C6O2)C=C1
Synonyms

ABBV-2222 (Standard); GLPG-2222 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Xueqing Wang, et al. Discovery of 4-[(2R,4R)-4-({[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropyl]carbonyl}amino)-7-(difluoromethoxy)-3,4-dihydro-2H-chromen-2-yl]benzoic Acid (ABBV/GLPG-2222), a Potent Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Corrector for the Treatment of Cystic Fibrosis. J Med Chem. 2018 Feb 22;61(4):1436-1449. [Content Brief]

[2]. Ashvani K Singh, et al. Biological Characterization of F508delCFTR Protein Processing by the CFTR Corrector ABBV-2222/GLPG2222. J Pharmacol Exp Ther. 2020 Jan;372(1):107-118. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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