ST6GALNAC1 - ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Gene

Also Known as STYI; SIAT7A; HSY11339; ST6GalNAcI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55808

Summary

Glycosylation of proteins affects cell-cell interaction, interactions with the matrix, and the functions of intracellular molecules. ST6GALNAC1 transfers a sialic acid, N-acetylneuraminic acid (NeuAc), in an alpha-2,6 linkage to O-linked GalNAc residues. The cancer-associated sialyl-Tn (sTn) antigen is formed by ST6GALNAC1-catalyzed sialylation of GalNAc residues on mucins (Ikehara et al., 1999 [PubMed 10536037]; Sewell et al., 2006 [PubMed 16319059]).[supplied by OMIM, Mar 2008]
Biased expression in colon (RPKM 93.3), small intestine (RPKM 34.8) and 7 other tissues.

ST6GALNAC1 Products (2)

mRNA Protein Name
NM_001289107.2 NP_001276036.1 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 2
NM_018414.5 NP_060884.1 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity IDA
IDA: Inferred from direct assay
16319059 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in protein glycosylation IDA
IDA: Inferred from direct assay
16319059 GOA
Cellular Component GO Annotation Evidence References Source
is active in Golgi membrane IDA
IDA: Inferred from direct assay
16319059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST6GALNAC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ST6GALNAC1 Q9NSC7 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
ST6GALNAC1 Q9NSC7 EEF1A2 Homo sapiens Q05639
Anti Tag CoIP
33961781
Intra
ST6GALNAC1 Q9NSC7 EEF1A2 Homo sapiens Q05639
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70150 ST6 Sialyltransferase 1 / Unkown
HY-P5045 Fmoc-Thr(GalNAc(Ac)3-β-D)-OH / Unkown
HY-RS16361 ST6GALNAC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25595 St6galnac1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown