1. Membrane Transporter/Ion Channel
  2. CFTR
  3. GLPG2451

GLPG2451 

Cat. No.: HY-119936
Handling Instructions

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM.

For research use only. We do not sell to patients.

GLPG2451 Chemical Structure

GLPG2451 Chemical Structure

CAS No. : 2055015-61-5

Size Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Customer Review

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].

IC50 & Target

Cystic fibrosis transmembrane conductance regulator[1]

In Vitro

GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

419.38

Formula

C₁₆H₁₆F₃N₃O₅S

CAS No.

2055015-61-5

SMILES

O=S(C1=CC=C(OC(F)(F)F)C=C1)(C2=CN=C(C(NC[[email protected]@H](O)C)=O)C(N)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GLPG2451
Cat. No.:
HY-119936
Quantity:

GLPG2451

Cat. No.: HY-119936