MYADM - myeloid associated differentiation marker Gene

Also Known as SB135

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91663

About MYADM

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:53,865,628-53,876,435 (from NCBI)

This gene has 11 transcripts (splice variants), 379 orthologues and 1 paralogue. Ubiquitous expression in lung (RPKM 50.4), gall bladder (RPKM 50.0) and 25 other tissues.

Summary

Involved in several processes, including negative regulation of heterotypic cell-cell adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein kinase C signaling. Located in several cellular components, including cortical actin cytoskeleton; membrane raft; and ruffle. [provided by Alliance of Genome Resources, Apr 2022]

MYADM Products (12)

mRNA Protein Name
NM_001020818.2 NP_001018654.1 myeloid-associated differentiation marker
NM_001020819.3 NP_001018655.1 myeloid-associated differentiation marker
NM_001020820.3 NP_001018656.1 myeloid-associated differentiation marker
NM_001020821.2 NP_001018657.1 myeloid-associated differentiation marker
NM_001290188.2 NP_001277117.1 myeloid-associated differentiation marker
NM_001290189.1 NP_001277118.1 myeloid-associated differentiation marker
NM_001290190.2 NP_001277119.1 myeloid-associated differentiation marker
NM_001290191.2 NP_001277120.1 myeloid-associated differentiation marker
NM_001290192.2 NP_001277121.1 myeloid-associated differentiation marker
NM_001290193.2 NP_001277122.1 myeloid-associated differentiation marker
NM_001290194.2 NP_001277123.1 myeloid-associated differentiation marker
NM_138373.5 NP_612382.1 myeloid-associated differentiation marker

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in cell-cell junction maintenance IMP
IMP: Inferred from mutant phenotype
23264465 GOA
involved in establishment of endothelial barrier IMP
IMP: Inferred from mutant phenotype
23264465 GOA
involved in intracellular signal transduction IMP
IMP: Inferred from mutant phenotype
23264465 GOA
involved in membrane raft organization IMP
IMP: Inferred from mutant phenotype
21325632 GOA
involved in negative regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
23264465 GOA
involved in negative regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23264465 GOA
involved in negative regulation of heterotypic cell-cell adhesion IDA
IDA: Inferred from direct assay
23264465 GOA
involved in positive regulation of cell migration IMP
IMP: Inferred from mutant phenotype
21325632 GOA
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
21325632 GOA
involved in protein localization to plasma membrane raft IMP
IMP: Inferred from mutant phenotype
21325632 GOA
NOT involved in regulation of cell-substrate adhesion IMP
IMP: Inferred from mutant phenotype
21325632 GOA
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23264465 GOA
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
21325632 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
21325632 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
23264465 GOA
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
21325632 GOA
located in ruffle IDA
IDA: Inferred from direct assay
21325632 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYADM Protein Structure

MARVEL

MARVEL: Membrane-associating domain (32 - 154)

MARVEL

MARVEL: Membrane-associating domain (169 - 312)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
Protein Preferred Names Protein Names

myeloid-associated differentiation marker

  • myeloid upregulated protein

MYADM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MYADM Q96S97 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
MYADM Q96S97 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 FIMP Homo sapiens Q96LL3
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 FIMP Homo sapiens Q96LL3
Y2H Array
32296183
Intra
MYADM Q96S97 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
MYADM Q96S97 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
MYADM Q96S97 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
MYADM Q96S97 ARF6 Homo sapiens P62330
Anti Tag CoIP
28514442
Intra
MYADM Q96S97 ARF6 Homo sapiens P62330
Anti Tag CoIP
33961781
Intra
MYADM Q96S97 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
MYADM Q96S97 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra
MYADM Q96S97 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra
MYADM Q96S97 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
MYADM Q96S97 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
MYADM Q96S97 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08868 MYADM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22659 Myadm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29173 Myadm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MYADM VGNC VGNC:68368
Mus musculus MYADM MGD MGI:1355332
Rattus norvegicus MYADM RGD RGD:727835
Others MYADM NCBI