CFTR corrector 2
Based on 1 publication(s) in Google Scholar
CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933.
For research use only. We do not sell to patients.
- Purity: 98.92%
- CAS No.: 1628416-28-3
- Formula: C27H23FN4O4
- Molecular Weight:486.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) CFTR corrector 2
More
Biological Activity
CFTR[1].
Chemical Information
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CAS No. 1628416-28-3
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Appearance Solid
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Molecular Weight 486.49
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Formula C27H23FN4O4
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Color White to off-white
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SMILES
O=C(N(C)C1=CC=C2N=C(C)OC2=C1)CN(N=C(C3=CC=CC(F)=C3)C4=C5C=C(OCC)C=C4)C5=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
PTI-801 (posenacaftor) shares a common mechanism with VX-445 (elexacaftor) to rescue p.Phe508del-CFTR. [Abstract]2024 Mar 15:967:176390. PMID: 38336013
Solvent & Solubility
DMSO : 62.5 mg/mL (128.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0555 mL | 10.2777 mL | 20.5554 mL | 51.3885 mL |
| 5 mM | 0.4111 mL | 2.0555 mL | 4.1111 mL | 10.2777 mL | |
| 10 mM | 0.2056 mL | 1.0278 mL | 2.0555 mL | 5.1389 mL | |
| 15 mM | 0.1370 mL | 0.6852 mL | 1.3704 mL | 3.4259 mL | |
| 20 mM | 0.1028 mL | 0.5139 mL | 1.0278 mL | 2.5694 mL | |
| 25 mM | 0.0822 mL | 0.4111 mL | 0.8222 mL | 2.0555 mL | |
| 30 mM | 0.0685 mL | 0.3426 mL | 0.6852 mL | 1.7130 mL | |
| 40 mM | 0.0514 mL | 0.2569 mL | 0.5139 mL | 1.2847 mL | |
| 50 mM | 0.0411 mL | 0.2056 mL | 0.4111 mL | 1.0278 mL | |
| 60 mM | 0.0343 mL | 0.1713 mL | 0.3426 mL | 0.8565 mL | |
| 80 mM | 0.0257 mL | 0.1285 mL | 0.2569 mL | 0.6424 mL | |
| 100 mM | 0.0206 mL | 0.1028 mL | 0.2056 mL | 0.5139 mL |
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