LPAR2 - lysophosphatidic acid receptor 2 Gene

Also Known as EDG4; LPA2; EDG-4; LPA-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9170

About LPAR2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,623,655-19,628,529 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 18 paralogues. Broad expression in testis (RPKM 11.9), bone marrow (RPKM 11.1) and 22 other tissues.

Summary

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

LPAR2 Products (7)

mRNA Protein Name
NM_001395660.1 NP_001382589.1 lysophosphatidic acid receptor 2
XM_017027469.2 XP_016882958.1 lysophosphatidic acid receptor 2 isoform X1
NM_004720.7
XM_024451774.2 XP_024307542.1 lysophosphatidic acid receptor 2 isoform X1
XM_047439678.1 XP_047295634.1 lysophosphatidic acid receptor 2 isoform X1
XM_017027468.3 XP_016882957.1 lysophosphatidic acid receptor 2 isoform X1
XM_047439679.1 XP_047295635.1 lysophosphatidic acid receptor 2 isoform X1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14688263 GOA
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
19306925 GOA
colocalizes with endocytic vesicle IDA
IDA: Inferred from direct assay
19306925 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 295)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
Protein Preferred Names Protein Names

lysophosphatidic acid receptor 2

  • G protein-coupled receptor

  • LPA receptor 2

  • LPA receptor EDG4

  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4

  • lysophosphatidic acid receptor EDG4

  • lysophosphatidic acid receptor Edg-4

LPAR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LPAR2 Q9HBW0 NHERF2 Homo sapiens Q15599
Pull Down
16203867
Intra
LPAR2 Q9HBW0 LGALS3 Homo sapiens P17931
Anti Tag CoIP
28514442
Intra
LPAR2 Q9HBW0 LGALS3 Homo sapiens P17931
Anti Tag CoIP
33961781
Intra
LPAR2 Q9HBW0 CFTR Homo sapiens P13569
Crosslink
16203867
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Secretory Diarrhea
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Cancer Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-107616 H2L5186303 Antagonist 98.50% Unkown
HY-100676 GRI977143 Agonist 99.29% Unkown
HY-148291 BrP-LPA sodium Antagonist / Unkown
HY-178845 Decyl phosphate Modulator / Unkown
HY-W725737 BrP-LPA Antagonist / Unkown
HY-118539 NSC12404 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LPAR2 VGNC VGNC:30956
Felis catus LPAR2 VGNC VGNC:63262
Mus musculus LPAR2 MGD MGI:1858422
Rattus norvegicus LPAR2 RGD RGD:1561336
Canis familiaris LPAR2 VGNC VGNC:42743
Macaca mulatta LPAR2 VGNC VGNC:74409
Others LPAR2 NCBI