BrP-LPA
BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior.
For research use only. We do not sell to patients.
- CAS No.: 944313-05-7
- Formula: C20H40BrO6P
- Molecular Weight:487.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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LPA1 Receptor |
LPA2 Receptor |
LPA3 Receptor |
LPA4 Receptor |
Chemical Information
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CAS No. 944313-05-7
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Molecular Weight 487.41
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Formula C20H40BrO6P
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SMILES
OP(O)(C(Br)C[C@H](O)COC(CCCCCCCCCCCCCCC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Xu X, et al. Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):140-6. [Content Brief]
[2]. Yamada M, et al. Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice. J Neural Transm (Vienna). 2015 Mar;122(3):487-94. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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