944313-05-7
944313-05-7
Chemical Structure
BrP-LPA
- CAS No.: 944313-05-7
- Formula:C20H40BrO6P
- Molecular Weight:487.41
InChIKey: HLVKVWDSLLFMSX-OYKVQYDMSA-N
SMILES: OP(O)(C(Br)C[C@H](O)COC(CCCCCCCCCCCCCCC)=O)=O
Biological Activity: BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior[1][2].
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BrP-LPA | BrP-LPA is a LPA antagonist/ATX inhibitor. BrP-LPA shows pan-antagonist activity towards LPA1-4 GPCRs. BrP-LPA decreases blood vessel density. BrP-LPA dose-dependently inhibits Lysophosphatidic acid-induced head-dip counts. BrP-LPA exhibits anticancer activity against breast cancer, colon cancer, and lung cancer. BrP-LPA inhibits anxiety-like behavior. | |||||||||||||||||||||
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References
- [1]. Xu X, et al. Evaluating dual activity LPA receptor pan-antagonist/autotaxin inhibitors as anti-cancer agents in vivo using engineered human tumors. Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):140-6. [Content Brief]
- [2]. Yamada M, et al. Lysophosphatidic acid induces anxiety-like behavior via its receptors in mice. J Neural Transm (Vienna). 2015 Mar;122(3):487-94. [Content Brief]
Keywords
