NHERF2 - NHERF family PDZ scaffold protein 2 Gene

Also Known as SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHE3RF2; NHERF-2; SLC9A3R2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9351

Summary

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

NHERF2 Products (5)

mRNA Protein Name
NM_001130012.3 NP_001123484.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform a
NM_001252073.2 NP_001239002.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform c
NM_001252075.2 NP_001239004.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform d
NM_001252076.2 NP_001239005.1 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform e
NM_004785.6 NP_004776.3 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 isoform b

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
17242191 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
22587461 GOA
enables phosphatase binding IPI
IPI: Inferred from physical interaction
16456542 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9054412 GOA
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
16456542 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11786550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

Na(+)/H(+) exchange regulatory cofactor NHE-RF2

  • NHE3 kinase A regulatory protein E3KARP

NHERF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NHERF2 Q15599 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
NHERF2 Q15599 YAP1 Homo sapiens P46937
TAP
27173435
Intra
NHERF2 Q15599 YAP1 Homo sapiens P46937
Pull Down
16166090
Intra
NHERF2 Q15599 CFTR Homo sapiens P13569
Pull Down
12369822
Intra
NHERF2 Q15599 DLGAP4 Homo sapiens Q9Y2H0-1
Validated Y2H
32296183
Intra
NHERF2 Q15599 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Array
32296183
Intra
NHERF2 Q15599 DLGAP4 Homo sapiens Q9Y2H0-1
Y2H Prey Pooling
32296183
Cross
NHERF2 Q15599 nleH1-1 Escherichia coli O157:H7 Q8X831
Far-WB
20618342
Cross
NHERF2 Q15599 nleH1-1 Escherichia coli O157:H7 Q8X831
IF
20618342
Cross
NHERF2 Q15599 nleH1-1 Escherichia coli O157:H7 Q8X831
Protein Array
20618342
Cross
NHERF2 Q15599 nleH1-1 Escherichia coli O157:H7 Q8X831
Anti Tag CoIP
20618342
Intra
NHERF2 Q15599 TRAF4 Homo sapiens Q9BUZ4
Y2H Prey Pooling
32296183
Intra
NHERF2 Q15599 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
NHERF2 Q15599 SRY Homo sapiens Q05066
Anti Bait CoIP
9054412
Intra
NHERF2 Q15599 SRY Homo sapiens Q05066
Far-WB
9054412
Intra
NHERF2 Q15599 SRY Homo sapiens Q05066
Pull Down
9054412
Intra
NHERF2 Q15599 SRY Homo sapiens Q05066
Y2H
9054412
Intra
NHERF2 Q15599 SRY Homo sapiens Q05066
Pull Down
16166090
Intra
NHERF2 Q15599 PODXL Homo sapiens O00592
Anti Tag CoIP
33961781
Intra
NHERF2 Q15599 PTEN Homo sapiens P60484
Filter Binding
16456542
Intra
NHERF2 Q15599 PTEN Homo sapiens P60484
Pull Down
16456542
Intra
NHERF2 Q15599 PTEN Homo sapiens P60484
Anti Tag CoIP
16456542
Intra
NHERF2 Q15599 PTEN Homo sapiens P60484
Anti Bait CoIP
16456542
Intra
NHERF2 Q15599 WWP2 Homo sapiens O00308
Y2H Prey Pooling
32296183
Intra
NHERF2 Q15599 WWP2 Homo sapiens O00308
Y2H Array
32296183
Intra
NHERF2 Q15599 LPAR2 Homo sapiens Q9HBW0
Pull Down
16203867
Cross
NHERF2 Q15599 Sry Mus musculus Q05738
IF
16166090
Intra
NHERF2 Q15599 SLC26A3 Homo sapiens P40879
Pull Down
12369822
Cross
NHERF2 Q15599 map Escherichia coli O127:H6 B7UMA0
Protein Array
20618342
Cross
NHERF2 Q15599 map Escherichia coli O127:H6 B7UMA0
Far-WB
20618342
Cross
NHERF2 Q15599 map Escherichia coli O127:H6 B7UMA0
IF
20618342
Cross
NHERF2 Q15599 b7ur60_eco27 Escherichia coli O127:H6 B7UR60
Far-WB
20618342
Cross
NHERF2 Q15599 b7ur60_eco27 Escherichia coli O127:H6 B7UR60
Anti Tag CoIP
20618342
Cross
NHERF2 Q15599 b7ur60_eco27 Escherichia coli O127:H6 B7UR60
IF
20618342
Cross
NHERF2 Q15599 mGluR1a Rattus norvegicus Q9R0W0
Protein Array
19027007
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09283 NHERF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown