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STAU1 - staufen double-stranded RNA binding protein 1 Gene

Also Known as STAU; PPP1R150

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6780

About STAU1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,113,339-49,219,295 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues.

Summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

STAU1 Products (14)

mRNA	Protein	Name
NM_001037328.3	NP_001032405.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319134.2	NP_001306063.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319135.2	NP_001306064.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322927.2	NP_001309856.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001322928.2	NP_001309857.1	double-stranded RNA-binding protein Staufen homolog 1 isoform d
NM_001322929.2	NP_001309858.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322930.2	NP_001309859.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322931.2	NP_001309860.1	double-stranded RNA-binding protein Staufen homolog 1 isoform e
NM_001322932.2	NP_001309861.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_001322933.2	NP_001309862.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_004602.4	NP_004593.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017452.4	NP_059346.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017453.4	NP_059347.2	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_017454.4	NP_059348.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15121898	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation by virus of viral protein levels in host cell	IMP IMP: Inferred from mutant phenotype	23907398	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	23907398	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell body	IDA IDA: Inferred from direct assay	15121898	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19029303	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
located in dendrite	IDA IDA: Inferred from direct assay	15121898	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23907398	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	22978549	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STAU1 Protein Structure

dsrm

0
100
200
300
400
500
577 a.a.

Protein Preferred Names	Protein Names
double-stranded RNA-binding protein Staufen homolog 1	protein phosphatase 1, regulatory subunit 150

STAU1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STAU1	O95793	ADARB1	Homo sapiens	P78563-4	Validated Y2H	32296183
Intra	STAU1	O95793	LONRF1	Homo sapiens	Q17RB8	Validated Y2H	32296183
Intra	STAU1	O95793	LONRF1	Homo sapiens	Q17RB8	Y2H Array	25416956
Intra	STAU1	O95793	ZMAT3	Homo sapiens	Q9HA38	Y2H Array	25416956
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Y2H Prey Pooling	25416956
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Validated Y2H	32296183
Intra	STAU1	O95793	NXT1	Homo sapiens	Q9UKK6	Y2H Array	25416956
Cross	STAU1	O95793	Klf4	Mus musculus	Q60793	Anti Tag CoIP	29374155
Intra	STAU1	O95793	RPLP0	Homo sapiens	P05388	Affinity Chrom	15303970
Intra	STAU1	O95793	RPLP0	Homo sapiens	P05388	TAP	15121898
Intra	STAU1	O95793	RPL7A	Homo sapiens	P62424	Affinity Chrom	15303970
Intra	STAU1	O95793	RPL7A	Homo sapiens	P62424	Anti Tag CoIP	33961781
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Anti Tag CoIP	23722113
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Complementation	15680326
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Far-WB	15680326
Intra	STAU1	O95793	UPF1	Homo sapiens	Q92900	Pull Down	15680326
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Y2H Array	25416956
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Y2H Prey Pooling	25416956
Intra	STAU1	O95793	GLRX3	Homo sapiens	O76003	Validated Y2H	25416956
Intra	STAU1	O95793	STRBP	Homo sapiens	Q96SI9	Validated Y2H	32296183
Cross	STAU1	O95793	NS	Influenza A virus	P03496	Y2H Array	23853584

Cross: Cross-species interaction Intra: Intraspecies interaction

STAU1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82332	Staufen Antibody (YA2077)	WB, IHC-P	Human, Mouse, Rat
HY-P82332A	Staufen Antibody (YA2077)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Philophthalmiasis
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Intellectual Developmental Disorder, Autosomal Dominant 1	MRD1 Autosomal Dominant Non-Syndromic Intellectual Disability 1 Mental Retardation, Autosomal Dominant 1 Autosomal Dominant Intellectual Developmental Disorder 1
Meckel Diverticulum	Meckel'S Diverticulum Persistent Vitelline Duct

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13900	STAU1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STAU1	MGD	MGI:1338864
Canis familiaris	STAU1	VGNC	VGNC:46893
Macaca mulatta	STAU1	VGNC	VGNC:77909
Rattus norvegicus	STAU1	RGD	RGD:621778
Bos taurus	STAU1	VGNC	VGNC:35375
Felis catus	STAU1	VGNC	VGNC:65764
Others	STAU1	NCBI