STAU1 - staufen double-stranded RNA binding protein 1 Gene

Homo sapiens

Also known as STAU; PPP1R150

Gene ID: 6780 | Gene type: protein coding

About STAU1

Cytogenetic location: 20q13.13 Genomic coordinates (GRCh38): 20:49,113,339-49,219,295 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 14 paralogues. Ubiquitous expression in kidney (RPKM 41.4), thyroid (RPKM 35.8) and 25 other tissues.

Summary

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. [provided by RefSeq, Apr 2020]

STAU1 Products(14)

mRNA	Protein	Name
NM_001037328.3	NP_001032405.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319134.2	NP_001306063.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001319135.2	NP_001306064.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322927.2	NP_001309856.1	double-stranded RNA-binding protein Staufen homolog 1 isoform c
NM_001322928.2	NP_001309857.1	double-stranded RNA-binding protein Staufen homolog 1 isoform d
NM_001322929.2	NP_001309858.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322930.2	NP_001309859.1	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_001322931.2	NP_001309860.1	double-stranded RNA-binding protein Staufen homolog 1 isoform e
NM_001322932.2	NP_001309861.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_001322933.2	NP_001309862.1	double-stranded RNA-binding protein Staufen homolog 1 isoform f
NM_004602.4	NP_004593.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017452.4	NP_059346.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a
NM_017453.4	NP_059347.2	double-stranded RNA-binding protein Staufen homolog 1 isoform b
NM_017454.4	NP_059348.2	double-stranded RNA-binding protein Staufen homolog 1 isoform a

STAU1 Protein Structure

dsrm

0
100
200
300
400
500
577 a.a.

Protein Preferred Names

Protein Names

double-stranded RNA-binding protein Staufen homolog 1

protein phosphatase 1, regulatory subunit 150

Related Diseases

Diseases

Alias

Philophthalmiasis

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Intellectual Developmental Disorder, Autosomal Dominant 1

MRD1	Autosomal Dominant Non-Syndromic Intellectual Disability 1
Mental Retardation, Autosomal Dominant 1	Autosomal Dominant Intellectual Developmental Disorder 1

Meckel Diverticulum

Meckel'S Diverticulum

Persistent Vitelline Duct

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13900	STAU1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	STAU1	MGD	MGI:1338864
Canis familiaris	STAU1	VGNC	VGNC:46893
Macaca mulatta	STAU1	VGNC	VGNC:77909
Rattus norvegicus	STAU1	RGD	RGD:621778
Bos taurus	STAU1	VGNC	VGNC:35375
Felis catus	STAU1	VGNC	VGNC:65764

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