NXT1 - nuclear transport factor 2 like export factor 1 Gene

Also Known as P15; MTR2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29107

About NXT1

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:23,350,791-23,354,771 (from NCBI)

This gene has 1 transcript (splice variant), 90 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 13.5), testis (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

NXT1 Products (1)

mRNA	Protein	Name
NM_013248.3	NP_037380.1	NTF2-related export protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11566096	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	25628361	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of nuclear RNA export factor complex	IPI IPI: Inferred from physical interaction	25628361	GOA
located in nucleus	IDA IDA: Inferred from direct assay	25628361	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NXT1 Protein Structure

NTF2

0
100
140 a.a.

Protein Preferred Names	Protein Names
NTF2-related export protein 1	NTF2-like export factor 1

NXT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NXT1	Q9UKK6	PAXIP1	Homo sapiens	Q6ZW49-2	Y2H Prey Pooling	25416956
Intra	NXT1	Q9UKK6	STAU1	Homo sapiens	O95793	Y2H Array	32296183
Intra	NXT1	Q9UKK6	STAU1	Homo sapiens	O95793	Y2H Prey Pooling	32296183
Intra	NXT1	Q9UKK6	STAU1	Homo sapiens	O95793	Validated Y2H	25416956
Intra	NXT1	Q9UKK6	NXF1	Homo sapiens	Q9UBU9	Pull Down	23299939
Intra	NXT1	Q9UKK6	NXF3	Homo sapiens	Q9H4D5	Y2H Pooling	16189514
Intra	NXT1	Q9UKK6	NXF3	Homo sapiens	Q9H4D5	Y2H Array	31515488
Cross	NXT1	Q9UKK6	Ranbp21	Drosophila melanogaster	Q9BP41	CoIP	12483225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anterior Horn Cell Disease
St. Louis Encephalitis	Saint Louis Encephalitis Neuroinvasive St. Louis Encephalitis Virus Infection Encephalitis, St. Louis Neuroinvasive Saint Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Infection St. Louis Encephalitis Virus Neuroinvasive Disease St. Louis Viral Disease Type C Lethargic Encephalitis Encephalitis Type C
Retinitis Pigmentosa 34	RP34
Lethal Congenital Contracture Syndrome 1	LCCS1 Multiple Contracture Syndrome, Finnish Type Lccs Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures Lethal Congenital Contracture Syndrome Type 1 Herva Disease Multiple Contracture Syndrome Finnish Type Contracture Syndrome, Lethal, Congenital, Type 1
Lethal Congenital Contracture Syndrome	Lccs Lethal Congenital Contracture Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09720	NXT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NXT1	MGD	MGI:1929619
Felis catus	NXT1	VGNC	VGNC:63940
Bos taurus	NXT1	VGNC	VGNC:32384
Rattus norvegicus	NXT1	RGD	RGD:1309327
Macaca mulatta	NXT1	VGNC	VGNC:75408
Others	NXT1	NCBI