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RPLP0 - ribosomal protein lateral stalk subunit P0 Gene

Also Known as P0; LP0; L10E; RPP0; PRLP0

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6175

About RPLP0

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,196,699-120,201,111 (from NCBI)

This gene has 27 transcripts (splice variants), 181 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 1127.2), bone marrow (RPKM 877.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPLP0 Products (2)

mRNA	Protein	Name
NM_001002.4	NP_000993.1	60S acidic ribosomal protein P0
NM_053275.4	NP_444505.1	60S acidic ribosomal protein P0

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15121898	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	3323886	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19188445	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	3323886	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19188445	GOA
is active in postsynapse	EXP EXP: Inferred from Experiment	23071613	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	23071613	GOA
is active in postsynaptic density	EXP EXP: Inferred from Experiment	21170055	GOA
is active in postsynaptic density	IDA IDA: Inferred from direct assay	21170055	GOA
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPLP0 Protein Structure

Ribosomal_L10

Ribosomal_60s

0
100
200
300
317 a.a.

Protein Preferred Names	Protein Names
60S acidic ribosomal protein P0	60S ribosomal protein L10E

RPLP0 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	CoIP	15303970
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	Anti Tag CoIP	33961781
Intra	RPLP0	P05388	STAU1	Homo sapiens	O95793	Affinity Chrom	15303970
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	33961781
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	28514442
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	RPLP0	P05388	CCNDBP1	Homo sapiens	O95273	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chagas Disease	American Trypanosomiasis Chagas' Disease Chagas' Disease With Digestive System Involvement Chagas' Disease With Nervous System Involvement Chagas' Disease With Other Organ Involvement Infection Due To Trypanosoma Cruzi South American Trypanosomiasis Chronic Chagas Disease With Digestive System Involvement
Mixed Connective Tissue Disease	Sharp Syndrome Mctd Connective Tissue Disease Overlap Syndrome Mixed Collagen Vascular Disease Mctd - [Mixed Connective Tissue Disease]
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Myopathy, Tubular Aggregate, 1	Tubular Aggregate Myopathy Tam Myopathy With Tubular Aggregates TAM1 Myopathy, Tubular Aggregate Tubular Aggregate Myopathy 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12207	RPLP0 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21040	Rplp0 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27557	Rplp0 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPLP0	MGD	MGI:1927636
Felis catus	RPLP0	VGNC	VGNC:82551
Bos taurus	RPLP0	VGNC	VGNC:107262
Rattus norvegicus	RPLP0	RGD	RGD:621247