ZMAT3 - zinc finger matrin-type 3 Gene

Also Known as WIG1; WIG-1; PAG608

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 64393

About ZMAT3

Cytogenetic location: 3q26.32 Genomic coordinates (GRCh38): 3:179,017,223-179,072,513 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and 9 paralogues. Ubiquitous expression in brain (RPKM 11.2), gall bladder (RPKM 5.6) and 24 other tissues.

Summary

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

ZMAT3 Products (8)

mRNA Protein Name
NM_001375824.1 NP_001362753.1 zinc finger matrin-type protein 3 isoform 1
NM_001375825.1 NP_001362754.1 zinc finger matrin-type protein 3 isoform 1
NM_001375826.1 NP_001362755.1 zinc finger matrin-type protein 3 isoform 2
NM_001375827.1 NP_001362756.1 zinc finger matrin-type protein 3 isoform 2
NM_001375828.1 NP_001362757.1 zinc finger matrin-type protein 3 isoform 2
NM_001375829.1 NP_001362758.1 zinc finger matrin-type protein 3 isoform 2
NM_022470.4 NP_071915.1 zinc finger matrin-type protein 3 isoform 1
NM_152240.3 NP_689426.1 zinc finger matrin-type protein 3 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
18519039 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZMAT3 Protein Structure

zf-met

zf-met: Zinc-finger of C2H2 type (70 - 94)

zf-met

zf-met: Zinc-finger of C2H2 type (148 - 171)

zf-C2H2_jaz

zf-C2H2_jaz: Zinc-finger double-stranded RNA-binding (245 - 271)

  • 0
  • 100
  • 200
  • 289 a.a.
Protein Preferred Names Protein Names

zinc finger matrin-type protein 3

  • WIG-1/PAG608 protein

ZMAT3 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ZMAT3 Q9HA38 HNRNPA2B1 Homo sapiens P22626
Anti Tag CoIP
18519039
Intra
ZMAT3 Q9HA38 HNRNPA2B1 Homo sapiens P22626
Anti Bait CoIP
18519039
Intra
ZMAT3 Q9HA38 DHX9 Homo sapiens Q08211
Anti Bait CoIP
18519039
Intra
ZMAT3 Q9HA38 DHX9 Homo sapiens Q08211
Anti Tag CoIP
18519039
Intra
ZMAT3 Q9HA38 STAU1 Homo sapiens O95793
Validated Y2H
25416956
Intra
ZMAT3 Q9HA38 STAU1 Homo sapiens O95793
Y2H Prey Pooling
25416956
Intra
ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Anti Bait CoIP
23085987
Intra
ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Pull Down
23085987
Intra
ZMAT3 Q9HA38 AGO2 Homo sapiens Q9UKV8
Anti Tag CoIP
23085987
Intra
ZMAT3 Q9HA38 PRKRA Homo sapiens O75569
Y2H Array
25416956
Intra
ZMAT3 Q9HA38 SIAH1 Homo sapiens Q8IUQ4
Validated Y2H
25416956
Intra
ZMAT3 Q9HA38 SIAH1 Homo sapiens Q8IUQ4
Y2H Array
25416956
Intra
ZMAT3 Q9HA38 TARBP2 Homo sapiens Q15633
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS16085 ZMAT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus ZMAT3 MGD MGI:1195270
Bos taurus ZMAT3 VGNC VGNC:37192
Macaca mulatta ZMAT3 VGNC VGNC:79831
Canis familiaris ZMAT3 VGNC VGNC:48640
Felis catus ZMAT3 VGNC VGNC:67253
Rattus norvegicus ZMAT3 RGD RGD:620134
Others ZMAT3 NCBI