PRKRA - protein activator of interferon induced protein kinase EIF2AK2 Gene

Also Known as RAX; PACT; DYT16; HSD14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8575

About PRKRA

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,431,414-178,451,175 (from NCBI)

This gene has 36 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 15.5), endometrium (RPKM 12.4) and 25 other tissues.

Summary

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral Infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

PRKRA Products (4)

mRNA	Protein	Name
NM_001139517.1	NP_001132989.1	interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2
NM_001139518.1	NP_001132990.1	interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 3
NM_001316362.2	NP_001303291.1	interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 4
NM_003690.5	NP_003681.1	interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	23661684	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	23661684	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	23661684	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16424907	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17452327	GOA
enables protein kinase activator activity	IDA IDA: Inferred from direct assay	29170442	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	23661684	GOA
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	26454002	GOA
involved in miRNA processing	IDA IDA: Inferred from direct assay	23661684	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	16424907	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	16424907	GOA
involved in siRNA processing	IDA IDA: Inferred from direct assay	17452327	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RISC-loading complex	IDA IDA: Inferred from direct assay	23661684	GOA
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	23661684	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	22214662	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17452327	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKRA Protein Structure

dsrm

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
interferon-inducible double-stranded RNA-dependent protein kinase activator A	PKR-associated protein X

PRKRA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRKRA	O75569	CEBPZ	Homo sapiens	Q03701	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	ZMAT4	Homo sapiens	Q9H898-2	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	ZMAT4	Homo sapiens	Q9H898-2	Validated Y2H	32296183
Intra	PRKRA	O75569	ZMAT4	Homo sapiens	Q9H898-2	Complementation	32296183
Intra	PRKRA	O75569	ZMAT4	Homo sapiens	Q9H898-2	Y2H Array	32296183
Intra	PRKRA	O75569	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
Intra	PRKRA	O75569	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	ADARB1	Homo sapiens	P78563-4	Validated Y2H	32296183
Intra	PRKRA	O75569	EHHADH	Homo sapiens	Q08426	Validated Y2H	32296183
Cross	PRKRA	O75569	N	SARS-CoV-2	P0DTC9	Confocal	35075101
Cross	PRKRA	O75569	N	SARS-CoV-2	P0DTC9	Y2H Array	36217030
Cross	PRKRA	O75569	N	SARS-CoV-2	P0DTC9	Anti Tag CoIP	35075101
Intra	PRKRA	O75569	ZMAT3	Homo sapiens	Q9HA38	Validated Y2H	25416956
Intra	PRKRA	O75569	ZMAT3	Homo sapiens	Q9HA38	Y2H Prey Pooling	25416956
Intra	PRKRA	O75569	PIAS2	Homo sapiens	O75928-2	Validated Y2H	32296183
Intra	PRKRA	O75569	PIAS2	Homo sapiens	O75928-2	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	PIAS2	Homo sapiens	O75928-2	Y2H Array	32296183
Intra	PRKRA	O75569	STAU1	Homo sapiens	O95793	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	STAU1	Homo sapiens	O95793	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	STAU1	Homo sapiens	O95793	Validated Y2H	32296183
Intra	PRKRA	O75569	STAU1	Homo sapiens	O95793	Y2H Array	32296183
Intra	PRKRA	O75569	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	16424907
Intra	PRKRA	O75569	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	IFIH1	Homo sapiens	Q9BYX4	Anti Tag CoIP	28591694
Intra	PRKRA	O75569	EIF2AK2	Homo sapiens	P19525	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	EIF2AK2	Homo sapiens	P19525	Validated Y2H	32296183
Intra	PRKRA	O75569	EIF2AK2	Homo sapiens	P19525	Y2H Array	32296183
Intra	PRKRA	O75569	LYAR	Homo sapiens	Q9NX58	Y2H Array	31515488
Intra	PRKRA	O75569	LYAR	Homo sapiens	Q9NX58	Validated Y2H	25416956
Intra	PRKRA	O75569	LYAR	Homo sapiens	Q9NX58	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Validated Y2H	32296183
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H Array	25416956
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H	21900206
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H Array	32296183
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Validated Y2H	25910212
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H Bait-Prey Pool	25910212
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H Array	25910212
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Anti Tag CoIP	16424907
Intra	PRKRA	O75569	TARBP2	Homo sapiens	Q15633	Y2H Prey Pooling	32296183
Intra	PRKRA	O75569	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	PRKRA	O75569	STRBP	Homo sapiens	Q96SI9	Validated Y2H	32296183
Cross	PRKRA	O75569	N	Human SARS coronavirus	P59595	Confocal	28591694
Cross	PRKRA	O75569	N	Human SARS coronavirus	P59595	Anti Tag CoIP	28591694
Intra	PRKRA	O75569	NKRF	Homo sapiens	O15226	Anti Tag CoIP	33961781
Intra	PRKRA	O75569	RIGI	Homo sapiens	O95786	Anti Tag CoIP	23870315
Intra	PRKRA	O75569	RIGI	Homo sapiens	O95786	Anti Tag CoIP	28591694
Cross	PRKRA	O75569	PA	Influenza A virus	Q67020	Y2H	21994455
Cross	PRKRA	O75569	NS	Influenza A virus	P03496	Y2H Array	23853584
Cross	PRKRA	O75569	NS	Influenza A virus	P03496	Y2H	20064372
Cross	PRKRA	O75569	N	Murine coronavirus	P03416	Anti Tag CoIP	28591694

Cross: Cross-species interaction Intra: Intraspecies interaction

PRKRA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81777	PRKRA Antibody (YA1522)	WB	Human, Mouse, Rat
HY-P81777A	PRKRA Antibody (YA1522)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Dystonia 16	DYT16 Dyt-Prkra Dystonia-16 Young-Onset Dystonia- Early-Onset Dystonia Parkinsonism Dystonia, Type 16
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Multifocal Dystonia
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Spasmodic Dystonia	Laryngeal Dystonia
Dystonia, Dopa-Responsive	Dystonia 5 Dopa-Responsive Dystonia DRD Dyt5 Dystonia-Parkinsonism With Diurnal Fluctuation Dyt-Th Hpd With Diurnal Fluctuation Hereditary Progressive Dystonia With Diurnal Fluctuation Dystonia, Progressive, With Diurnal Variation Segawa Syndrome, Autosomal Dominant Dystonia, Dopa-Responsive, Autosomal Dominant Dopa-Responsive Dystonia, Autosomal Dominant Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia Dyt-Gch1 Dyt-Spr Dystonia 5, Dopa-Responsive Type Hereditary Progressive Dystonia With Marked Diurnal Fluctuation Autosomal Dominant Dopa-Responsive Dystonia Autosomal Dominant Segawa Syndrome Dystonia-5 Progressive Dystonia With Diurnal Fluctuation Dystonia, Type 5, Dopa-Responsive Type
Middle East Respiratory Syndrome	Mers Mers - [Middle East Respiratory Syndrome]
Cervical Dystonia	Spasmodic Torticollis
Rhizomelic Chondrodysplasia Punctata, Type 3	Rhizomelic Chondrodysplasia Punctata Type 3 RCDP3 Alkyldihydroxyacetonephosphate Synthase Deficiency Alkylglycerone-Phosphate Synthase Deficiency Agps Deficiency Rhizomelic Chondrodysplasia Punctata 3 Chondrodysplasia Punctata, Rhizomelic, Type 3
Segmental Dystonia
Acute Ethmoiditis	Acute Ethmoidal Sinusitis Acute Ethmoid Sinusitis Ethmoidal Sinus - Acute
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Deafness, Autosomal Recessive 109	DFNB109 Autosomal Recessive Nonsyndromic Deafness 109 Autosomal Recessive Deafness 109 Deafness, Autosomal Recessive, 109
Focal Dystonia	Dystonia, Focal, Task-Specific
Paraneoplastic Polyneuropathy
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia
Leukodystrophy, Hypomyelinating, 6	Habc Hypomyelinating Leukodystrophy 6 HLD6 H-Abc Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum HLD Leukodystrophy, Hypomyelinating, Type 6
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Movement Disease	Movement Disorders Movement Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0891	Tubeimoside II		99.90%	Unkown
HY-RS11157	PRKRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKRA	MGD	MGI:1344375
Rattus norvegicus	PRKRA	RGD	RGD:1306707
Canis familiaris	PRKRA	VGNC	VGNC:44991
Bos taurus	PRKRA	VGNC	VGNC:33343
Macaca mulatta	PRKRA	VGNC	VGNC:76421
Felis catus	PRKRA	VGNC	VGNC:69073
Others	PRKRA	NCBI