1. Gene
  2. PRKRA - protein activator of interferon induced protein kinase EIF2AK2 Gene

PRKRA - protein activator of interferon induced protein kinase EIF2AK2 Gene

Homo sapiens

Also known as RAX; PACT; DYT16; HSD14

Gene ID: 8575 | Gene type: protein coding

About PRKRA

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,431,414-178,451,175 (from NCBI)

This gene has 36 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 15.5), endometrium (RPKM 12.4) and 25 other tissues.

Summary

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral Infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

PRKRA Products(4)

mRNA Protein Name
NM_001139517.1 NP_001132989.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2
NM_001139518.1 NP_001132990.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 3
NM_001316362.2 NP_001303291.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 4
NM_003690.5 NP_003681.1 interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1

PRKRA Protein Structure

dsrm

dsrm: Double-stranded RNA binding motif (35 - 99)

dsrm

dsrm: Double-stranded RNA binding motif (127 - 191)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

interferon-inducible double-stranded RNA-dependent protein kinase activator A

PKR-associated protein X

Related Diseases

Diseases Alias
Dystonia 16

DYT16

Dyt-Prkra

Dystonia-16

Young-Onset Dystonia-

Early-Onset Dystonia Parkinsonism

Dystonia, Type 16

Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia

Multifocal Dystonia
Parkinsonism

Parkinsonism-Plus

Idiopathic Parkinsonism

Primary Parkinsonism

Paralysis Agitans Syndrome

Parkinsonian Syndrome

Trembling Paralysis

Paralysis Agitans

Shaking Palsy

Shaking Paralysis

Spasmodic Dystonia

Laryngeal Dystonia

Dystonia, Dopa-Responsive

Dystonia 5

Dopa-Responsive Dystonia

DRD

Dyt5

Dystonia-Parkinsonism With Diurnal Fluctuation

Dyt-Th

Hpd With Diurnal Fluctuation

Hereditary Progressive Dystonia With Diurnal Fluctuation

Dystonia, Progressive, With Diurnal Variation

Segawa Syndrome, Autosomal Dominant

Dystonia, Dopa-Responsive, Autosomal Dominant

Dopa-Responsive Dystonia, Autosomal Dominant

Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia

Dyt-Gch1

Dyt-Spr

Dystonia 5, Dopa-Responsive Type

Hereditary Progressive Dystonia With Marked Diurnal Fluctuation

Autosomal Dominant Dopa-Responsive Dystonia

Autosomal Dominant Segawa Syndrome

Dystonia-5

Progressive Dystonia With Diurnal Fluctuation

Dystonia, Type 5, Dopa-Responsive Type

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Cervical Dystonia

Spasmodic Torticollis

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3

RCDP3

Alkyldihydroxyacetonephosphate Synthase Deficiency

Alkylglycerone-Phosphate Synthase Deficiency

Agps Deficiency

Rhizomelic Chondrodysplasia Punctata 3

Chondrodysplasia Punctata, Rhizomelic, Type 3

Segmental Dystonia
Acute Ethmoiditis

Acute Ethmoidal Sinusitis

Acute Ethmoid Sinusitis

Ethmoidal Sinus - Acute

Dystonia 3, Torsion, X-Linked

X-Linked Dystonia-Parkinsonism

DYT3

Xdp

Lubag

Dystonia-Parkinsonism, X-Linked

Torsion Dystonia-Parkinsonism, Filipino Type

Dyt-Taf1

X-Linked Dystonia-Parkinsonism Syndrome

X-Linked Torsion Dystonia-Parkinsonism Syndrome

Dystonia Musculorum Deformans

X-Linked Dystonia-Parkinsonism/Lubag

Lubag Syndrome

Dystonia-3

Torsion Dystonia-Parkinsonism Filipino Type

X-Linked Torsion Dystonia 3

Dystonia, Torsion, X-Linked, Type 3

Deafness, Autosomal Recessive 109

DFNB109

Autosomal Recessive Nonsyndromic Deafness 109

Autosomal Recessive Deafness 109

Deafness, Autosomal Recessive, 109

Focal Dystonia

Dystonia, Focal, Task-Specific

Paraneoplastic Polyneuropathy
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders

Treacher Collins Syndrome 1

Treacher Collins Syndrome

Mandibulofacial Dysostosis

Treacher Collins-Franceschetti Syndrome

Tcof

Tcs

Mfd1

Franceschetti-Klein Syndrome

TCS1

Franceschetti Syndrome

Franceschetti-Zwahlen-Klein Syndrome

Zygoauromandibular Dysplasia

Treacher-Collins Syndrome

Mandibulofacial Dysostosis Without Limb Anomalies

Bilateral And Symmetric Oto-Mandibular Dysplasia

Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6

Alternating Hemiplegia Of Childhood

Alternating Hemiplegia

Ahc

Alternating Hemiplegia Syndrome

Hemiplegia, Alternating, Of Childhood

Hemiplegia, Crossed

Movement Disease

Movement Disorders

Movement Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PRKRA MGD MGI:1344375
Rattus norvegicus PRKRA RGD RGD:1306707
Canis familiaris PRKRA VGNC VGNC:44991
Bos taurus PRKRA VGNC VGNC:33343
Macaca mulatta PRKRA VGNC VGNC:76421
Felis catus PRKRA VGNC VGNC:69073