CEBPZ - CCAAT enhancer binding protein zeta Gene

Also Known as CBF; CBF2; NOC1; HSP-CBF

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10153

About CEBPZ

Cytogenetic location: 2p22.2 Genomic coordinates (GRCh38): 2:37,201,612-37,231,596 (from NCBI)

This gene has 3 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in testis (RPKM 27.1), adrenal (RPKM 18.8) and 25 other tissues.

Summary

This gene belongs to the CBF/Mak21 family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. [provided by RefSeq, Nov 2020]

CEBPZ Products (1)

mRNA Protein Name
NM_005760.3 NP_005751.2 CCAAT/enhancer-binding protein zeta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables DNA binding IDA
IDA: Inferred from direct assay
11306579 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21900206 GOA
enables transcription coactivator activity IGI
IGI: Inferred from genetic interaction
11306579 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
2247079 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11306579 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEBPZ Protein Structure

CBF

CBF: CBF/Mak21 family (522 - 732)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1054 a.a.
Protein Preferred Names Protein Names

CCAAT/enhancer-binding protein zeta

  • CCAAT-box-binding transcription factor

CEBPZ Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEBPZ Q03701 PRKRA Homo sapiens O75569
Y2H
21900206
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Opportunistic Bacterial Infectious Disease
Nocardiosis

  • Nocardia Infection

  • Nocardia Infections

  • Nocardia Infectious Disease

  • Lung Nocardiosis

  • Nocardiasis

  • Nocardiosis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03614 DDIT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS02450 CEBPZ Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CEBPZ VGNC VGNC:71082
Felis catus CEBPZ VGNC VGNC:60741
Mus musculus CEBPZ MGD MGI:109386
Canis familiaris CEBPZ VGNC VGNC:39090
Rattus norvegicus CEBPZ RGD RGD:1304994
Bos taurus CEBPZ VGNC VGNC:27164
Others CEBPZ NCBI