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LYAR - Ly1 antibody reactive Gene

Also Known as ZLYAR; ZC2HC2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55646

About LYAR

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:4,267,701-4,290,154 (from NCBI)

This gene has 4 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 46.8), lymph node (RPKM 8.5) and 20 other tissues.

Summary

Enables several functions, including DNA-binding transcription factor binding activity; identical protein binding activity; and transcription regulator inhibitor activity. Involved in several processes, including erythrocyte development; negative regulation of innate immune response; and regulation of transcription, DNA-templated. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LYAR Products (2)

mRNA	Protein	Name
NM_001145725.2	NP_001139197.1	cell growth-regulating nucleolar protein
NM_017816.3	NP_060286.1	cell growth-regulating nucleolar protein

LYAR Protein Structure

zf-LYAR

0
100
200
300
379 a.a.

Protein Preferred Names	Protein Names
cell growth-regulating nucleolar protein	Ly1 antibody reactive homolog

LYAR Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LYAR	Q9NX58	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	25416956
Intra	LYAR	Q9NX58	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	25416956
Intra	LYAR	Q9NX58	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
Intra	LYAR	Q9NX58	PRKRA	Homo sapiens	O75569	Y2H	21516116
Intra	LYAR	Q9NX58	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	LYAR	Q9NX58	PRKRA	Homo sapiens	O75569	Y2H Prey Pooling	25416956
Intra	LYAR	Q9NX58	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
Intra	LYAR	Q9NX58	FBL	Homo sapiens	P22087	Anti Bait CoIP	17353931
Intra	LYAR	Q9NX58	PRKRA	Homo sapiens	O75569	Y2H Array	25416956
Intra	LYAR	Q9NX58	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
Intra	LYAR	Q9NX58	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07909	LYAR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LYAR	RGD	RGD:1305352
Felis catus	LYAR	VGNC	VGNC:63336
Mus musculus	LYAR	MGD	MGI:107470
Bos taurus	LYAR	VGNC	VGNC:31095
Macaca mulatta	LYAR	VGNC	VGNC:74364
Canis familiaris	LYAR	VGNC	VGNC:42879
Others	LYAR	NCBI