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TARBP2 - TARBP2 subunit of RISC loading complex Gene

Also Known as LOQS; TRBP; TRBP1; TRBP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6895

About TARBP2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,500,923-53,506,431 (from NCBI)

This gene has 20 transcripts (splice variants), 211 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 7.8), testis (RPKM 6.1) and 25 other tissues.

Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene. [provided by RefSeq, Jul 2008]

TARBP2 Products (3)

mRNA	Protein	Name
NM_004178.5	NP_004169.3	RISC-loading complex subunit TARBP2 isoform b
NM_134323.2	NP_599150.1	RISC-loading complex subunit TARBP2 isoform a
NM_134324.3	NP_599151.2	RISC-loading complex subunit TARBP2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	23661684	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	25557550	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA
contributes to pre-miRNA binding	IDA IDA: Inferred from direct assay	18178619	GOA
enables pre-miRNA binding	IDA IDA: Inferred from direct assay	23435228	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15973356	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	17452327	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	30927622	GOA
enables siRNA binding	IDA IDA: Inferred from direct assay	15973356	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	15973356	GOA
involved in global gene silencing by mRNA cleavage	IMP IMP: Inferred from mutant phenotype	15973356	GOA
involved in miRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA
involved in negative regulation of cytoplasmic pattern recognition receptor signaling pathway	IDA IDA: Inferred from direct assay	30927622	GOA
involved in negative regulation of defense response to virus by host	IDA IDA: Inferred from direct assay	11641396	GOA
involved in positive regulation of viral genome replication	IDA IDA: Inferred from direct assay	11641396	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA
involved in regulation of viral transcription	IDA IDA: Inferred from direct assay	11641396	GOA
involved in siRNA processing	IDA IDA: Inferred from direct assay	15973356	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RISC complex	IDA IDA: Inferred from direct assay	17531811	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	15973356	GOA
part of RISC-loading complex	IPI IPI: Inferred from physical interaction	23661684	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17452327	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TARBP2 Protein Structure

dsrm

0
100
200
300
366 a.a.

Protein Preferred Names	Protein Names
RISC-loading complex subunit TARBP2	TAR (HIV) RNA-binding protein 2

TARBP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TARBP2	Q15633	PNKP	Homo sapiens	Q96T60	Validated Y2H	32296183
Intra	TARBP2	Q15633	ZMAT4	Homo sapiens	Q9H898-2	Validated Y2H	32296183
Intra	TARBP2	Q15633	ZMAT4	Homo sapiens	Q9H898-2	Y2H Prey Pooling	32296183
Intra	TARBP2	Q15633	ZMAT4	Homo sapiens	Q9H898-2	Y2H Array	32296183
Intra	TARBP2	Q15633	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	TARBP2	Q15633	ZNF346	Homo sapiens	Q9UL40	Validated Y2H	25416956
Intra	TARBP2	Q15633	ZNF346	Homo sapiens	Q9UL40	Validated Y2H	32296183
Intra	TARBP2	Q15633	ZNF346	Homo sapiens	Q9UL40	Y2H Array	32296183
Intra	TARBP2	Q15633	ZNF346	Homo sapiens	Q9UL40	Y2H Prey Pooling	32296183
Intra	TARBP2	Q15633	ZMAT3	Homo sapiens	Q9HA38	Y2H Array	32296183
Intra	TARBP2	Q15633	ZMAT3	Homo sapiens	Q9HA38	Validated Y2H	32296183
Intra	TARBP2	Q15633	DICER1	Homo sapiens	Q9UPY3	Anti Bait CoIP	16142218
Intra	TARBP2	Q15633	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	23622242
Intra	TARBP2	Q15633	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	16424907
Intra	TARBP2	Q15633	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	23622242
Intra	TARBP2	Q15633	ADAR	Homo sapiens	P55265-5	Anti Tag CoIP	23622242
Intra	TARBP2	Q15633	PRKRA	Homo sapiens	O75569	Y2H Prey Pooling	25416956
Intra	TARBP2	Q15633	PRKRA	Homo sapiens	O75569	Validated Y2H	25416956
Intra	TARBP2	Q15633	STRBP	Homo sapiens	Q96SI9	Validated Y2H	25416956
Intra	TARBP2	Q15633	STRBP	Homo sapiens	Q96SI9	Y2H Prey Pooling	25416956
Intra	TARBP2	Q15633	TCEANC	Homo sapiens	Q8N8B7	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

TARBP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81688	TARBP2 Antibody (YA1433)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pleuropulmonary Blastoma	PPB Ppb Familial Tumor And Dysplasia Syndrome Ppbftds Pulmonary Blastoma Blastoma, Pleuropulmonary Dicer1 Syndrome Respiratory Tract Neoplasms
Dicer1 Syndrome	Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 X-Linked Intellectual Disability And Macroorchidism Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Primary Immunodeficiency Disease Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14207	TARBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TARBP2	RGD	RGD:1307375
Macaca mulatta	TARBP2	VGNC	VGNC:78099
Mus musculus	TARBP2	MGD	MGI:103027
Canis familiaris	TARBP2	VGNC	VGNC:47108
Bos taurus	TARBP2	VGNC	VGNC:35602
Felis catus	TARBP2	VGNC	VGNC:65954
Others	TARBP2	NCBI