NKRF - NFKB repressing factor Gene

Also Known as NRF; ITBA4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55922

About NKRF

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:119,588,337-119,606,424 (from NCBI)

This gene has 5 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 6.5), lymph node (RPKM 4.2) and 25 other tissues.

Summary

This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

NKRF Products (1)

mRNA	Protein	Name
NM_017544.5	NP_060014.3	NF-kappa-B-repressing factor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase activator activity	IDA IDA: Inferred from direct assay	32179686	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	10562553	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10562553	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21900206	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10562553	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10562553	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10562553	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NKRF Protein Structure

G-patch

R3H

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
NF-kappa-B-repressing factor	transcription factor NRF

NKRF Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NKRF	O15226	ADARB1	Homo sapiens	P78563-4	Validated Y2H	32296183
Intra	NKRF	O15226	ADARB1	Homo sapiens	P78563-4	Y2H Prey Pooling	32296183
Intra	NKRF	O15226	ADARB1	Homo sapiens	P78563-4	Y2H Array	32296183
Intra	NKRF	O15226	DHX15	Homo sapiens	O43143	Y2H Prey Pooling	32296183
Intra	NKRF	O15226	DHX15	Homo sapiens	O43143	Validated Y2H	32296183
Intra	NKRF	O15226	DHX15	Homo sapiens	O43143	Y2H Array	32296183
Intra	NKRF	O15226	ZNF346	Homo sapiens	Q9UL40	Y2H Prey Pooling	32296183
Intra	NKRF	O15226	ZNF346	Homo sapiens	Q9UL40	Y2H Array	32296183
Intra	NKRF	O15226	ZNF346	Homo sapiens	Q9UL40	Validated Y2H	32296183
Intra	NKRF	O15226	STAU1	Homo sapiens	O95793	Validated Y2H	32296183
Intra	NKRF	O15226	STAU1	Homo sapiens	O95793	Y2H Prey Pooling	32296183
Intra	NKRF	O15226	STAU1	Homo sapiens	O95793	Y2H Array	32296183
Intra	NKRF	O15226	PRKRA	Homo sapiens	O75569	Y2H Prey Pooling	32296183
Intra	NKRF	O15226	PRKRA	Homo sapiens	O75569	Validated Y2H	32296183
Intra	NKRF	O15226	PRKRA	Homo sapiens	O75569	Y2H Array	32296183
Intra	NKRF	O15226	PRKRA	Homo sapiens	O75569	Y2H	21900206

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Lymphocytic Choriomeningitis	Lcm Lymphocytic Meningitis Lymphocytic Choriomeningitis Virus Encephalomyelitis Lymphocytic Meningoencephalitis Non-Arthropod Borne Lymphocytic Choriomeningitis Lcm - [Lymphocytic Choriomeningitis] Benign Lymphocytic Meningitis Meningitis Due To Lymphocytic Choriomeningitis Virus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09323	NKRF Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21393	Nkrf Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27912	Nkrf Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NKRF	VGNC	VGNC:52805
Mus musculus	NKRF	MGD	MGI:1924536
Rattus norvegicus	NKRF	RGD	RGD:6500424
Canis familiaris	NKRF	VGNC	VGNC:54177
Macaca mulatta	NKRF	VGNC	VGNC:75214
Felis catus	NKRF	VGNC	VGNC:63816
Others	NKRF	NCBI