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RPL7A - ribosomal protein L7a Gene

Also Known as L7A; TRUP; SURF3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 6130

About RPL7A

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,348,218-133,351,426 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 137 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 1676.2), bone marrow (RPKM 795.5) and 25 other tissues.

Summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including Thyroid Hormone Receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the Trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of Trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPL7A Products (1)

mRNA	Protein	Name
NM_000972.3	NP_000963.1	60S ribosomal protein L7a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15303970	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	32669547	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA
located in membrane	IDA IDA: Inferred from direct assay	10848616	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	25294810	GOA
located in ribosome	IDA IDA: Inferred from direct assay	10848616	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL7A Protein Structure

Ribosomal_L7Ae

0
100
200
266 a.a.

Protein Preferred Names	Protein Names
60S ribosomal protein L7a	PLA-X polypeptide

RPL7A Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	RPL7A	P62424	RPL7L1	Homo sapiens	Q6DKI1	Anti Tag CoIP	33961781
Intra	RPL7A	P62424	RSL1D1	Homo sapiens	O76021	Crosslink	30021884
Intra	RPL7A	P62424	RSL1D1	Homo sapiens	O76021	Anti Tag CoIP	33961781
Intra	RPL7A	P62424	STAU1	Homo sapiens	O95793	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

RPL7A 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83114	RPL7A Antibody (YA2859)	WB, IHC-P	Human, Mouse, Rat

関連疾患

Diseases	Alias
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS12204	RPL7A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	RPL7A	MGD	MGI:1353472
Canis familiaris	RPL7A	VGNC	VGNC:55813
Bos taurus	RPL7A	VGNC	VGNC:49957
Rattus norvegicus	RPL7A	RGD	RGD:1307586
Others	RPL7A	NCBI