TRIM/RBCC Proteins
The TRIM/RBCC proteins form one of the largest E3 ligase families in humans, defined by a tripartite motif of RING finger, one or two B-box domains, and a coiled-coil region. The RING recruits ubiquitin-loaded E2s, the coiled-coil drives dimerization, and variable C-terminal domains (PRY-SPRY, COS-box, NHL, and others) determine substrate selection, letting members such as TRIM5-alpha, TRIM21, and TRIM28 act in antiviral restriction, autoimmunity, and transcriptional silencing. TRIM ligases also shape innate immune signaling and are implicated in cancer and muscular disease. Recombinant TRIM proteins are widely used to study substrate ubiquitination, antiviral restriction assays, and ligase-directed drug discovery.
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TRIM/RBCC Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
