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Cat. No.: HY-126394B

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Bamocaftor potassium

(Synonyms: VX-659 potassium)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research.

For research use only. We do not sell to patients.

CAS No.: 2204245-47-4
Formula: C₂₈H₃₂F₃KN₅O₄S
Molecular Weight:630.74

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Bamocaftor potassium Chemical Structure

CAS No.: 2204245-47-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 2204245-47-4
Molecular Weight 630.74
Formula C₂₈H₃₂F₃KN₅O₄S
SMILES

O=C(C1=CC=C(N2N=C(OCCC3(C(F)(F)F)CC3)C=C2)N=C1N4C(C)(C)C[C@H](C)C4)NS(=O)(C5=CC=CC=C5)=O.[K]
Synonyms

VX-659 potassium
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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PNAS Nexus

VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels. [Abstract]

2025 Jul 4;4(7):pgaf211. PMID: 40688096

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ghelani DP, et al. Emerging Cystic Fibrosis Transmembrane Conductance Regulator Modulators as New Drugs for Cystic Fibrosis: A Portrait of in Vitro Pharmacology and Clinical Translation. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Bamocaftor potassium

1 Cited Publications

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Bamocaftor potassium

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Publications (1)

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Bamocaftor potassium Related Classifications

HY-126394B Related Classifications