1. Membrane Transporter/Ion Channel
  2. CFTR
  3. Tezacaftor

Tezacaftor (Synonyms: VX-661)

Cat. No.: HY-15448 Purity: 99.92% ee.: 99.28%
Handling Instructions

Tezacaftor (VX-661) is a second F508del CFTR corrector and help CFTR protein reach the cell surface.

For research use only. We do not sell to patients.

Tezacaftor Chemical Structure

Tezacaftor Chemical Structure

CAS No. : 1152311-62-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 103 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg USD 590 In-stock
Estimated Time of Arrival: December 31
200 mg USD 950 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

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  • References

Description

Tezacaftor (VX-661) is a second F508del CFTR corrector and help CFTR protein reach the cell surface.

In Vitro

In vitro, a combination of Tezacaftor (VX-661) and ivacaftor results in greater CFTR activity compared with Tezacaftor (VX-661) alone[2].

Clinical Trial
Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (192.12 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9212 mL 9.6061 mL 19.2123 mL
5 mM 0.3842 mL 1.9212 mL 3.8425 mL
10 mM 0.1921 mL 0.9606 mL 1.9212 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.80 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

520.50

Formula

C₂₆H₂₇F₃N₂O₆

CAS No.

1152311-62-0

SMILES

O=C(C1(C2=CC=C(OC(F)(F)O3)C3=C2)CC1)NC4=CC5=C(N(C[[email protected]@H](O)CO)C(C(C)(C)CO)=C5)C=C4F

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.92% ee.: 99.28%

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Tezacaftor
Cat. No.:
HY-15448
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Tezacaftor

Cat. No.: HY-15448