SH3BP4 - SH3 domain binding protein 4 Gene

Homo sapiens

Also known as TTP; BOG25

Gene ID: 23677 | Gene type: protein coding

About SH3BP4

Cytogenetic location: 2q37.2 Genomic coordinates (GRCh38): 2:234,952,017-235,055,714 (from NCBI)

This gene has 11 transcripts (splice variants), 277 orthologues and 1 paralogue. Ubiquitous expression in salivary gland (RPKM 12.0), gall bladder (RPKM 8.4) and 24 other tissues.

Summary

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

SH3BP4 Products(6)

mRNA	Protein	Name
NM_001371302.1	NP_001358231.1	SH3 domain-binding protein 4
NM_001371303.1	NP_001358232.1	SH3 domain-binding protein 4
NM_001371304.1	NP_001358233.1	SH3 domain-binding protein 4
NM_001371305.1	NP_001358234.1	SH3 domain-binding protein 4
NM_001371306.1	NP_001358235.1	SH3 domain-binding protein 4
NM_014521.3	NP_055336.1	SH3 domain-binding protein 4

SH3BP4 Protein Structure

SH3_9

ZU5

SH3_2

0
200
400
600
800
963 a.a.

Protein Preferred Names

Protein Names

SH3 domain-binding protein 4

EH-binding protein 10

Related Diseases

Diseases

Alias

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Metacarpal 4-5 Fusion

Syndactyly Type 8	MF4
Fusion Of Metacarpals 4 And 5	Metacarpals 4 And 5 Fusion
Metacarpal 4 5 Fusion

Cardiomyopathy, Familial Hypertrophic, 2

Hypertrophic Cardiomyopathy 2	CMH2
Cardiomyopathy, Hypertrophic, 2	Cardiomyopathy Familial Hypertrophic 2
Cardiomyopathy, Familial Hypertrophic 2	Cardiomyopathy, Hypertrophic, Familial, Type 2

Waardenburg Syndrome, Type 4a

Waardenburg-Shah Syndrome	Shah-Waardenburg Syndrome
Waardenburg Syndrome Type 4a	WS4A
Ws4	Waardenburg Syndrome Type 4
Waardenburg Syndrome Type Iva	Waardenburg Syndrome With Hirschsprung Disease Type 4a
Hirschsprung Disease With Pigmentary Anomaly	Waardenburg-Hirschsprung Syndrome
Waardenburg Syndrome, Type Iva	Waardenburg Syndrome With Hirschsprung Disease, Type 4a
Waardenburg-Hirschsprung Disease	Waardenburg Syndrome, Type 4
Waardenburg Syndrome 4a

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12832	SH3BP4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SH3BP4	RGD	RGD:620219
Canis familiaris	SH3BP4	VGNC	VGNC:46119
Macaca mulatta	SH3BP4	VGNC	VGNC:77202
Bos taurus	SH3BP4	VGNC	VGNC:34567
Felis catus	SH3BP4	VGNC	VGNC:65102
Mus musculus	SH3BP4	MGD	MGI:2138297

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