CIZ1 - CDKN1A interacting zinc finger protein 1 Gene

Also Known as NP94; LSFR1; ZNF356

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25792

About CIZ1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,166,065-128,204,222 (from NCBI)

This gene has 28 transcripts (splice variants), 243 orthologues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues.

Summary

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

CIZ1 Products (7)

mRNA	Protein	Name
NM_001131015.2	NP_001124487.1	cip1-interacting zinc finger protein isoform 2
NM_001131016.2	NP_001124488.1	cip1-interacting zinc finger protein isoform 1
NM_001131017.2	NP_001124489.1	cip1-interacting zinc finger protein isoform 3
NM_001131018.2	NP_001124490.1	cip1-interacting zinc finger protein isoform 4
NM_001257975.2	NP_001244904.1	cip1-interacting zinc finger protein isoform 5
NM_001257976.2	NP_001244905.1	cip1-interacting zinc finger protein isoform 6
NM_012127.3	NP_036259.2	cip1-interacting zinc finger protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18654987	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	23145069	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CIZ1 Protein Structure

zf-C2H2_jaz

0
200
400
600
800
898 a.a.

Protein Preferred Names	Protein Names
cip1-interacting zinc finger protein	nuclear protein NP94

CIZ1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CIZ1	Q9ULV3	SH3BP4	Homo sapiens	Q9P0V3	Y2H	18654987

Cross: Cross-species interaction Intra: Intraspecies interaction

CIZ1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89942	CIZ1 Antibody (YA9286)	WB, IP	human

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 31	DEE31 Epileptic Encephalopathy, Early Infantile, 31 Eiee31 Developmental And Epileptic Encephalopathy, 31 Early Infantile Epileptic Encephalopathy 31 Encephalopathy, Epileptic, Early Infantile, Type 31
Cervical Dystonia	Spasmodic Torticollis
Dystonia 23	DYT23 Adult-Onset Cervical Dystonia, Dyt23 Type Dystonia, Type 23
Motor Stereotypies	Motor Stereotypy
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Focal Dystonia	Dystonia, Focal, Task-Specific
Torsion Dystonia 2	Dystonia 2, Torsion, Autosomal Recessive
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Hypotonia
Dystonia 25	DYT25 Dystonia-25 Dystonia, Type 25
Torsion Dystonia 4
Dystonia 1, Torsion, Autosomal Dominant	Dystonia Musculorum Deformans 1 Dystonia Musculorum Deformans DYT1 Early-Onset Torsion Dystonia Eotd Dystonia-1, Torsion Torsion Dystonia 1 Autosomal Dominant Torsion Dystonia 1 Dystonia-1 Oppenheim'S Dystonia Oppenheim-Ziehen Disease Early Onset Torsion Dystonia Dystonia 3, Torsion, X-Linked
Torticollis	Contracture Of Neck Wry Neck Wry Neck/Torticollis
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Segmental Dystonia
Dystonia 6, Torsion	DYT6 Torsion Dystonia 6 Dystonia 6 Idiopathic Torsion Dystonia Of Mixed Type Primary Dystonia, Dyt6 Type Torsion Dystonia, Adult-Onset, Mixed Type Dyt-Thap1 Adolescent-Onset Dystonia Of Mixed Type Torsion Dystonia Adult Onset Mixed Type Dyt6 Dystonia Thap1 Dystonia Generalized Cervical And Upper-Limb-Onset Dystonia Adult-Onset Torsion Dystonia Mixed Type Autosomal Dominant Torsion Dystonia 6 Dystonia-6 Torsion Dystonia Type 6 Dystonia, Type 6, Torsion
Dystonia 27	DYT27 Primary Dystonia, Dyt27 Type Dystonia, Type 27
Multifocal Dystonia
Spasmodic Dystonia	Laryngeal Dystonia
Jaw Cancer	Jaw Neoplasms Jaw Neoplasm Neoplasm Of Jaw Cancer Of Jaw
Leukodystrophy, Hypomyelinating, 6	Habc Hypomyelinating Leukodystrophy 6 HLD6 H-Abc Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum HLD Leukodystrophy, Hypomyelinating, Type 6
Hereditary Lymphedema Ii	Meige Syndrome Meige Disease Meige Lymphedema Hereditary Lymphedema Type Ii Lymphedema Hereditary Type 2 Lymphedema Praecox Lymphedema, Hereditary, Ii Blepharospasm-Oromandibular Dystonia Syndrome Meige Dystonia Meige'S Syndrome Late-Onset Lymphedema Lmph2 Lymphedema Preacox Lymphedema, Late-Onset Blepharospasm - Oromandibular Dystonia Blepharospasm-Oromandibular Dystonia Brueghel Syndrome Idiopathic Blepharospasm-Oromandibular Dystonia Syndrome Oral Facial Dystonia Segmental Cranial Dystonia Meigs Syndrome
Blepharospasm
Oromandibular Dystonia
Hemidystonia
Lymphatic Malformation 5	Meige Syndrome Meige Disease Meige Lymphedema Lymphedema Praecox Lymphedema, Late-Onset Late-Onset Lymphedema LMPH2 Meigs Syndrome LMPHM5 Lymphedema, Hereditary, Ii, Formerly Lmph2, Formerly Hereditary Lymphedema Ii Demons-Meigs Syndrome Hereditary Lymphedema Type Ii Lymphedema, Hereditary, 2 Lymphedema, Hereditary, Ii Meige'S Disease
Alternating Hemiplegia Of Childhood	Alternating Hemiplegia Ahc Alternating Hemiplegia Syndrome Hemiplegia, Alternating, Of Childhood Hemiplegia, Crossed
Focal Hand Dystonia	Organic Writer'S Cramp Dystonia, Focal, Task-Specific
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Dystonia 11, Myoclonic	Myoclonic Dystonia Myoclonus-Dystonia Syndrome DYT11 Myoclonic Dystonia 11 Alcohol-Responsive Dystonia Myoclonus, Hereditary Essential Dystonia-11, Myoclonic Myoclonus-Dystonia Dystonia 11 Hereditary Essential Myoclonus Dystonia, Alcohol-Responsive Dyt-Sgce Dystonia, Alcohol Responsive Dystonia-11 Dystonia, Myoclonic Dystonia, Myoclonic, Type 11
Movement Disease	Movement Disorders Movement Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02731	CIZ1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CIZ1	VGNC	VGNC:27379
Macaca mulatta	CIZ1	VGNC	VGNC:71184
Rattus norvegicus	CIZ1	RGD	RGD:1305336
Mus musculus	CIZ1	MGD	MGI:1920234
Felis catus	CIZ1	VGNC	VGNC:60911
Canis familiaris	CIZ1	VGNC	VGNC:39285
Others	CIZ1	NCBI