USP10 - ubiquitin specific peptidase 10 Gene
Also Known as UBPO
Species: Homo sapiens
About USP10
This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues.
Summary
Ubiquitin is a highly conserved protein that is covalently linked to Other proteins to regulate their function and degradation. This gene encodes a member of the Ubiquitin-Specific Protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound Androgen Receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and Others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
USP10 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001272075.2 | NP_001259004.1 | ubiquitin carboxyl-terminal hydrolase 10 isoform 1 |
| NM_005153.3 | NP_005144.2 | ubiquitin carboxyl-terminal hydrolase 10 isoform 2 |
USP10 Protein Structure
UCH: Ubiquitin carboxyl-terminal hydrolase (415 - 792)
- 0
- 200
- 400
- 600
- 798 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
ubiquitin carboxyl-terminal hydrolase 10 |
|
USP10 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 25416956 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 25416956 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 33961781 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 29892012 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 19615732 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86 | 33495715 | |
|
Intra
|
USP10 | Q14694 | G3BP1 | Homo sapiens | Q13283 | 33961781 | |
|
Intra
|
USP10 | Q14694 | G3BP1 | Homo sapiens | Q13283 | 21455491 | |
|
Intra
|
USP10 | Q14694 | G3BP1 | Homo sapiens | Q13283 | 19615732 | |
|
Intra
|
USP10 | Q14694 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
USP10 | Q14694 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
USP10 | Q14694 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
USP10 | Q14694 | G3BP2 | Homo sapiens | Q9UN86-2 | 32296183 | |
|
Intra
|
USP10 | Q14694 | CFTR | Homo sapiens | P13569 | 35156780 | |
|
Intra
|
USP10 | Q14694 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
USP10 | Q14694 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
USP10 | Q14694 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
USP10 | Q14694 | ZC3H12A | Homo sapiens | Q5D1E8 | 24270572 | |
|
Intra
|
USP10 | Q14694 | ZC3H12A | Homo sapiens | Q5D1E8 | 24270572 |
USP10 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82617 | USP10 Antibody (YA2362) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
| HY-P82617A | USP10 Antibody (YA2362)(PBS only) | WB, IHC-F, IHC-P, ICC/IF, IP | Human |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | USP10 | VGNC | VGNC:36710 |
| Mus musculus | USP10 | MGD | MGI:894652 |
| Macaca mulatta | USP10 | VGNC | VGNC:103881 |
| Canis familiaris | USP10 | VGNC | VGNC:48178 |
| Rattus norvegicus | USP10 | RGD | RGD:1561965 |
| Others | USP10 | NCBI |