USP10 - ubiquitin specific peptidase 10 Gene

Homo sapiens

Also known as UBPO

Gene ID: 9100 | Gene type: protein coding

About USP10

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,700,000-84,779,922 (from NCBI)

This gene has 19 transcripts (splice variants), 216 orthologues and 71 paralogues. Ubiquitous expression in placenta (RPKM 15.2), lymph node (RPKM 13.4) and 25 other tissues.

Summary

Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the Ubiquitin-Specific Protease family of cysteine proteases. The Enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound Androgen Receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and Others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]

USP10 Products(2)

mRNA	Protein	Name
NM_001272075.2	NP_001259004.1	ubiquitin carboxyl-terminal hydrolase 10 isoform 1
NM_005153.3	NP_005144.2	ubiquitin carboxyl-terminal hydrolase 10 isoform 2

USP10 Protein Structure

UCH

0
200
400
600
798 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 10

deubiquitinating enzyme 10

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-12990	Spautin-1	99.27%	Unkown
HY-153886	Wu-5	99.34%	Unkown
HY-RS15521	USP10 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP10	VGNC	VGNC:36710
Mus musculus	USP10	MGD	MGI:894652
Macaca mulatta	USP10	VGNC	VGNC:103881
Canis familiaris	USP10	VGNC	VGNC:48178
Rattus norvegicus	USP10	RGD	RGD:1561965
Others	USP10	NCBI

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