2. Gene
  3. G3BP2 - G3BP stress granule assembly factor 2 Gene

G3BP2 - G3BP stress granule assembly factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 9908 | Gene type: protein coding

About G3BP2

Cytogenetic location: 4q21.1 Genomic coordinates (GRCh38): 4:75,642,786-75,724,437 (from NCBI)

This gene has 90 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 45.6), thyroid (RPKM 35.2) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of stress granule assembly and protein homooligomerization. Located in cytoplasmic stress granule and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

G3BP2 Products(21)

mRNA Protein Name
NM_001400004.1 NP_001386933.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400005.1 NP_001386934.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400006.1 NP_001386935.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400007.1 NP_001386936.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400008.1 NP_001386937.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400010.1 NP_001386939.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400011.1 NP_001386940.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400012.1 NP_001386941.1 ras GTPase-activating protein-binding protein 2 isoform a
NM_001400013.1 NP_001386942.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400014.1 NP_001386943.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400015.1 NP_001386944.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400016.1 NP_001386945.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400017.1 NP_001386946.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400018.1 NP_001386947.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400019.1 NP_001386948.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400020.1 NP_001386949.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_001400021.1 NP_001386950.1 ras GTPase-activating protein-binding protein 2 isoform c
NM_001400022.1 NP_001386951.1 ras GTPase-activating protein-binding protein 2 isoform d
NM_012297.5 NP_036429.2 ras GTPase-activating protein-binding protein 2 isoform a
NM_203504.3 NP_987100.1 ras GTPase-activating protein-binding protein 2 isoform b
NM_203505.3 NP_987101.1 ras GTPase-activating protein-binding protein 2 isoform a

G3BP2 Protein Structure

NTF2

NTF2: Nuclear transport factor 2 (NTF2) domain (11 - 133)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (333 - 390)

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  • 482 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating protein-binding protein 2

G3BP-2

Related Diseases

Diseases Alias
Mouth Disease

Mouth Diseases

Mouth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131649 Compound C108 98.66% Unkown
HY-160706 HHQ16 / Unkown
HY-RS05190 G3BP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta G3BP2 VGNC VGNC:100229
Bos taurus G3BP2 VGNC VGNC:29177
Mus musculus G3BP2 MGD MGI:2442040
Felis catus G3BP2 VGNC VGNC:78500
Rattus norvegicus G3BP2 RGD RGD:1309571
Canis familiaris G3BP2 VGNC VGNC:41039