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  4. HHQ16

HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling.

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HHQ16

HHQ16 Chemical Structure

CAS No. : 2620471-66-9

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HHQ16 Related Antibodies

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Description

HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling[1].

In Vitro

HHQ16 (100 nM, 6 h) binds to lnc9456 with high-affinity and induces its degradation in HL-1 mouse cardiomyocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HHQ16 Related Antibodies
In Vivo

HHQ16 (1- 100 mg/kg, oral gavage, daily for 4 weeks) effectively reverses the left anterior descending coronary artery ligation (LADL)-induced deterioration of cardiac function and structural remodeling in mice[1].
HHQ16 (10 mg/kg, p.o., 2 weeks) decreases the high level of lnc9456 in the heart and regress the remodeling associated changes in AAV-lnc9456 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: left anterior descending coronary artery ligation (LADL)-induced heart failure mice[1]
Dosage: 1- 100 mg/kg
Administration: oral gavage, daily for 4 weeks
Result: Increased theeft ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of the mice.
Reduced the enlarged heart size and the heart weight to body surface area ratio (HW/BSA).
Reversed LADL-induced hypertrophy by decreasing the cell volume (size) and slippage (disorderly aligned myocytes).
Reversed LADL-induced increase in ANP, BNP, β-MHC, and hypertrophic expression of ANP and BNP.
Molecular Weight

510.70

Formula

C30H48F2O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](C[C@H](O)[C@]2([H])[C@]3(C)O[C@H](C(C)(C)O)CC3)(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)C(F)(F)CC[C@]5(C6)[C@]46CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (195.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9581 mL 9.7905 mL 19.5810 mL
5 mM 0.3916 mL 1.9581 mL 3.9162 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.90 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
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% 
+
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%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.97%

SDS (252 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9581 mL 9.7905 mL 19.5810 mL 48.9524 mL
5 mM 0.3916 mL 1.9581 mL 3.9162 mL 9.7905 mL
10 mM 0.1958 mL 0.9790 mL 1.9581 mL 4.8952 mL
15 mM 0.1305 mL 0.6527 mL 1.3054 mL 3.2635 mL
20 mM 0.0979 mL 0.4895 mL 0.9790 mL 2.4476 mL
25 mM 0.0783 mL 0.3916 mL 0.7832 mL 1.9581 mL
30 mM 0.0653 mL 0.3263 mL 0.6527 mL 1.6317 mL
40 mM 0.0490 mL 0.2448 mL 0.4895 mL 1.2238 mL
50 mM 0.0392 mL 0.1958 mL 0.3916 mL 0.9790 mL
60 mM 0.0326 mL 0.1632 mL 0.3263 mL 0.8159 mL
80 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6119 mL
100 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.4895 mL
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HHQ16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HHQ162620471-66-9HHQ 16HHQ-16Drug DerivativeDrug derivativeinfarctionhypertrophyheart failurecardiomyocytesInhibitorinhibitorinhibit

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