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HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling.

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HHQ16 Chemical Structure

HHQ16 Chemical Structure

CAS No. : 2620471-66-9

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HHQ16 Related Antibodies

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Description

HHQ16 is an orally active derivative of Astragaloside IV (HY-N0431). HHQ16 effectively reverses infarction-induced hypertrophy and heart failure by targeted degrading lnc4012/lnc9456 and antagonizing their effects on G3BP2/NF-κB signaling[1].

In Vitro

HHQ16 (100 nM, 6 h) binds to lnc9456 with high-affinity and induces its degradation in HL-1 mouse cardiomyocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HHQ16 Related Antibodies
In Vivo

HHQ16 (1- 100 mg/kg, oral gavage, daily for 4 weeks) effectively reverses the left anterior descending coronary artery ligation (LADL)-induced deterioration of cardiac function and structural remodeling in mice[1].
HHQ16 (10 mg/kg, p.o., 2 weeks) decreases the high level of lnc9456 in the heart and regress the remodeling associated changes in AAV-lnc9456 mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: left anterior descending coronary artery ligation (LADL)-induced heart failure mice[1]
Dosage: 1- 100 mg/kg
Administration: oral gavage, daily for 4 weeks
Result: Increased theeft ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) of the mice.
Reduced the enlarged heart size and the heart weight to body surface area ratio (HW/BSA).
Reversed LADL-induced hypertrophy by decreasing the cell volume (size) and slippage (disorderly aligned myocytes).
Reversed LADL-induced increase in ANP, BNP, β-MHC, and hypertrophic expression of ANP and BNP.
Molecular Weight

510.70

Formula

C30H48F2O4
CAS No.
SMILES

C[C@@]12[C@](C[C@H](O)[C@]2([H])[C@]3(C)O[C@H](C(C)(C)O)CC3)(C)[C@]4([H])C[C@H](O)[C@@]5([H])C(C)(C)C(F)(F)CC[C@]5(C6)[C@]46CC1
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Purity & Documentation
References
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HHQ16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HHQ162620471-66-9HHQ 16HHQ-16Othersinfarctionhypertrophyheart failurecardiomyocytesInhibitorinhibitorinhibit

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