2. PROTAC
  3. Molecular Glues
  4. MRT-5702D

MRT-5702D is a G3BP2 molecular glue degrader. MRT-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. MRT-5702D can be used for research of G3BP2-related cancers and neurodegenerative diseases.

For research use only. We do not sell to patients.

MRT-5702D

MRT-5702D Chemical Structure

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MRT-5702D Related Antibodies

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Description

MRT-5702D is a G3BP2 molecular glue degrader. MRT-5702D forms a CRBN-MRT-5702D-G3BP2 ternary complex to activate the ubiquitin-proteasome system for G3BP2 degradation. MRT-5702D can be used for research of G3BP2-related cancers and neurodegenerative diseases[1].

IC50 & Target[1]

Cereblon

 

In Vitro

MRT-5702D potently induces ternary complex formation between recombinantly purified CRBN/DDB1 and G3BP2NTF2L in an in vitro TR-FRET assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MRT-5702D Related Antibodies
Molecular Weight

621.11

Formula

C30H29ClN6O5S
SMILES

C[C@H]1C2=CC=CC=C2C[C@H](N1S(=O)(CC3=CC=CC=C3Cl)=O)C(NCC4=CC5=NC=C(N5C=C4)N6CCC(NC6=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRT-5702D Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRT-5702DMolecular GluesubiquitinationUSP10HEK293T cellsCRL4CRBN E3 ubiquitin ligase complexNTF2L domainCAL51 cellsG3BP2Cereblonproteasome activityCRBNInhibitorinhibitorinhibit

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MRT-5702D
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HY-174329
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