1. Membrane Transporter/Ion Channel
  2. Chloride Channel
  3. Lubiprostone

Lubiprostone (Synonyms: RU-0211; SPI-0211)

Cat. No.: HY-B0679 Purity: >98.0%
Handling Instructions

Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation.

For research use only. We do not sell to patients.

Lubiprostone Chemical Structure

Lubiprostone Chemical Structure

CAS No. : 136790-76-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 102 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Lubiprostone(SPI-0211;RU0211) is a gastrointestinal agent used for the treatment of idiopathic chronic constipation. Target: Others Lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 that acts by specifically activating ClC-2 chloride channels on the apical aspect of gastrointestinal epithelial cells, producing a chloride-rich fluid secretion. These secretions soften the stool, increase motility, and promote spontaneous bowel movements (SBM). From Wikipedia.

Clinical Trial
Molecular Weight

390.46

Formula

C₂₀H₃₂F₂O₅

CAS No.

136790-76-6

SMILES

O=C(C(F)(F)CCCC)CC[[email protected]@H]([[email protected]@H](C1)O)[[email protected]](C1=O)CCCCCCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (256.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5611 mL 12.8054 mL 25.6108 mL
5 mM 0.5122 mL 2.5611 mL 5.1222 mL
10 mM 0.2561 mL 1.2805 mL 2.5611 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3.25 mg/mL (8.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3.25 mg/mL (8.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3.25 mg/mL (8.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

LubiprostoneRU-0211SPI-0211RU0211RU 0211SPI0211SPI 0211Chloride ChannelCl− ChannelsInhibitorinhibitorinhibit

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