ACCS - 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Gene

Also Known as ACS; PHACS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84680

About ACCS

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:44,066,270-44,084,237 (from NCBI)

This gene has 13 transcripts (splice variants), 149 orthologues and 7 paralogues. Ubiquitous expression in spleen (RPKM 11.2), gall bladder (RPKM 7.3) and 25 other tissues.

Summary

Enables identical protein binding activity. Predicted to be involved in biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]

ACCS Products (2)

mRNA Protein Name
NM_001127219.2 NP_001120691.1 1-aminocyclopropane-1-carboxylate synthase-like protein 1
NM_032592.4 NP_115981.1 1-aminocyclopropane-1-carboxylate synthase-like protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
NOT enables 1-aminocyclopropane-1-carboxylate synthase activity IDA
IDA: Inferred from direct assay
11470512 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACCS Protein Structure

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (98 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
Protein Preferred Names Protein Names

1-aminocyclopropane-1-carboxylate synthase-like protein 1

  • ACC synthase-like protein 1

ACCS Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACCS Q96QU6 UQCRB Homo sapiens P14927
Y2H Prey Pooling
25416956
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Y2H Array
31515488
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Y2H Prey Pooling
32296183
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6-1
Y2H Array
31515488
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Validated Y2H
32296183
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Y2H Array
25416956
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Y2H Array
32296183
Intra
ACCS Q96QU6 ACCS Homo sapiens Q96QU6
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Thyroid Dyshormonogenesis 5

  • TDH5

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5

  • Thyroid Hormonogenesis, Genetic Defect In, 5

  • Genetic Defect In Thyroid Hormonogenesis 5

  • Chdh5

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 5

  • Genetic Defect In Thyroid Hormonogenesis Type 5
Granulomatous Amebic Encephalitis

  • Granulomatous Amoebic Encephalitis

  • Acanthamoeba Encephalitis

  • Acanthamoeba Granulomatous Encephalitis

  • Granulomatous Amebic Encephalitis Due To Acanthamoeba
Twin-To-Twin Transfusion Syndrome

  • Twin To Twin Transfusion Syndrome

  • Twin Twin Transfusion Syndrome

  • Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin

  • Fetal Hemorrhage Into Co-Twin

  • Twin To Twin Transfusion

  • Twin-To-Twin Blood Transfer

  • Fetal Transfusion Syndrome

  • Fetofetal Transfusion Syndrome

  • Ttts

  • Feto-Fetal Transfusion Syndrome

  • Fetofetal Transfusion

  • Fetus-To-Fetus Placental Transfusion Syndrome
Primary Amebic Meningoencephalitis

  • Pam

  • Naegleria Fowleri Infection

  • Meningoencephalitis Caused By Naegleria Fowleri

  • Primary Amoebic Meningoencephalitis
Thyroid Dyshormonogenesis 4

  • Deiodinase Deficiency

  • TDH4

  • Iodotyrosine Dehalogenase Deficiency

  • Thyroid Hormonogenesis, Genetic Defect In, 4

  • Hypothyroidism, Congenital, Due To Dyshormonogenesis, 4

  • Genetic Defect In Thyroid Hormonogenesis 4

  • Chdh4

  • Congenital Hypothyroidism Due To Dyshormonogenesis Type 4

  • Genetic Defect In Thyroid Hormonogenesis Type 4
Aplasia Of Lacrimal And Salivary Glands

  • ALSG

  • Congenital Absence Of Lacrimal Puncta And Salivary Glands

  • Xerostomia

  • Absence Of Salivary Glands

  • Parotid Aplasia Or Hypoplasia

  • Congenital Absence Of Lacrimal Puncta Or Salivary Glands

  • Alsg - [Aplasia Of Lacrimal Or Salivary Glands]
Mucopolysaccharidosis, Type Ix

  • Mucopolysaccharidosis Type Ix

  • Hyaluronidase Deficiency

  • MPS9

  • Mps Ix

  • Mucopolysaccharidosis Ix

  • Mpsix

  • Mucopolysaccharidosis Type 9

  • Mucopolysaccharidosis 9
Neonatal Anemia

  • Anemia Neonatal

  • Anemia, Neonatal

  • Anaemia Neonatal

  • Neonatal Anaemia
Familial Thyroid Dyshormonogenesis

  • Thyroid Dyshormonogenesis

  • Familial Dyshormonogenetic Goiter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-17641 Olumacostat glasaretil Inhibitor 98.90% Phase 3
HY-16901 Firsocostat Inhibitor 99.96% Phase 2
HY-12942 PF-05175157 Inhibitor 98.10% Phase 2
HY-135981 CMS-121 Inhibitor 99.63% Phase 1
HY-107709 MK-4074 Inhibitor 99.12% Phase 1
HY-102066 Utatrectinib Inhibitor 98.72% Phase 1
HY-150191 IMA-1 / Phase 1
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99527 Vanutide cridificar / Phase 2

Pre-clinical Phase

Bioactive Molecules (58)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153367 FHD-609 Inhibitor 98.95% Unkown
HY-101842 ND-646 Inhibitor 99.13% Unkown
HY-D0067 7ACC1 Inhibitor 99.94% Unkown
HY-D0713 7ACC2 Inhibitor 99.95% Unkown
HY-12741 LDN-212320 Activator 98.92% Unkown
HY-125848 Ginsenoside F2 99.92% Unkown
HY-15259 CP-640186 Inhibitor 99.21% Unkown
HY-N0853 Alisol A 99.59% Unkown
HY-147004 A-908292 Inhibitor 99.88% Unkown
HY-79503 (Rp,R'p)-(R)-Mandyphos 92.59% Unkown
HY-119575 Tetramethyluric acid 99.63% Unkown
HY-15259A CP-640186 hydrochloride Inhibitor 99.65% Unkown
HY-160912 ELOVL6-IN-5 Inhibitor 95.12% Unkown
HY-100771 PCC0208009 Inhibitor 98.06% Unkown
HY-19624 NVP-ACC789 Inhibitor 99.52% Unkown
HY-W588256 12-Tridecenoic acid Activator 95.0% Unkown
HY-N0853A Alisol A 24-acetate 98.0% Unkown
HY-N0772 Isomangiferin 99.60% Unkown
HY-P10002 EWFW-ACC 96.59% Unkown
HY-147376 hACC2-IN-1 Inhibitor 99.86% Unkown
HY-152117 Acetyl-CoA Carboxylase-IN-1 Inhibitor 99.18% Unkown
HY-16901A Firsocostat (S enantiomer) 98.25% Unkown
HY-179537 CKBA Inhibitor 98.97% Unkown
HY-124609 CAD031 99.39% Unkown
HY-144701 SABA1 Inhibitor 99.15% Unkown
HY-147932 ACC1/2-IN-2 Inhibitor 99.00% Unkown
HY-P10003B iso-VQA-ACC acetate 99.48% Unkown
HY-120904 AMPK-IN-1 Activator 95.19% Unkown
HY-151931 JA-ACC / Unkown
HY-16943 Moiramide B Inhibitor 99.24% Unkown
HY-151931S JA-ACC-d3 99.0% Unkown
HY-42632 ACC1/2-IN-3 Inhibitor / Unkown
HY-N7521 Procyanidin C2 / Unkown
HY-115549 AMPK activator 18 Activator / Unkown
HY-127108 ND-654 Inhibitor / Unkown
HY-127128 Flestolol sulfate Inhibitor / Unkown
HY-137846A PF-05221304 tromethamine / Unkown
HY-147930 ACC1/2-IN-1 Inhibitor / Unkown
HY-148684 AMPK activator 10 Activator / Unkown
HY-161976 ACC1-IN-2 Inhibitor / Unkown
HY-169008 PROTAC ACC degrader-1 Degrader / Unkown
HY-169009 (Rac)-Spirotetramat-enol / Unkown
HY-169010 Pomalidomide-CO-C5-Br / Unkown
HY-16946 CP-610431 Inhibitor / Unkown
HY-173565 ACC-IN-1 Inhibitor / Unkown
HY-180575 LCB-2122 / Unkown
HY-19000 ACC-9358 Inhibitor / Unkown
HY-N16232 2-ACC / Unkown
HY-P10002A EWFW-ACC TFA / Unkown
HY-P10003 iso-VQA-ACC / Unkown
HY-P10003A iso-VQA-ACC TFA / Unkown
HY-RS00146 ACCS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121273 Diclofop Inhibitor / Unkown
HY-170931 AMPK activator 16 / Unkown
HY-178040 Insecticidal agent 26 Inhibitor / Unkown
HY-183919 ACC2-IN-1 Inhibitor / Unkown
HY-N10612 Petasin / Unkown
HY-N3055 Pinusolide 99.93% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACCS RGD RGD:1309314
Mus musculus ACCS MGD MGI:1919717
Others ACCS NCBI