2. Metabolic Enzyme/Protease
  3. Acetyl-CoA Carboxylase
  4. hACC2-IN-1

hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research.

For research use only. We do not sell to patients.

hACC2-IN-1 Chemical Structure

hACC2-IN-1 Chemical Structure

CAS No. : 192323-14-1

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hACC2-IN-1 Related Antibodies

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Description

hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1].

IC50 & Target

hACC2

2.5 μM (IC50)

In Vitro

ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol[1].
ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver[1].
hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hACC2-IN-1 Related Antibodies
Molecular Weight

432.58

Formula

C23H32N2O4S
CAS No.
SMILES

CC(C)(OC(NC[C@H]1CC[C@@H](CC1)CNS(=O)(C2=CC3=C(C=CC=C3)C=C2)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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hACC2-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hACC2-IN-1192323-14-1Acetyl-CoA CarboxylaseACC, Acetyl Coenzyme A Carboxylaseobese Zucker ratsacetyl-CoA carboxylasesACCsmalonyl-CoAligand lipophilicity efficiencyQuinolinehepatic malonyl-CoA levelInhibitorinhibitorinhibit

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hACC2-IN-1
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HY-147376
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