ACC1/2-IN-2
Based on 1 Customer Validation
ACC1/2-IN-2 (compound PF-3) is a potent ACC1/2 inhibitor with IC50 values of 22 and 48 nM for ACC1 and ACC2, respectively. ACC1/2-IN-2 has antiproliferation activity and can be used for cancer research.
For research use only. We do not sell to patients.
- Purity : 99.00%
- CAS No.: 1031411-94-5
- Formula: C24H25N3O3
- Molecular Weight:403.47
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
48 nM
Compound: 1
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Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay
Inhibition of human Acetyl-CoA carboxylase 2 expressed in CHO cells after 1 hr by fluorescence assay
|
[PMID: 22148323] |
| CHO | IC50 |
48 nM
Compound: 17
|
Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader
Inhibition of human recombinant ACC2 expressed in CHO cells after 1 hr by fluorescence reader
|
[PMID: 20219367] |
Chemical Information
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CAS No. 1031411-94-5
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Appearance Solid
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Molecular Weight 403.47
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Formula C24H25N3O3
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Color White to off-white
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SMILES
O=C1CC2(CCN(C(C3=CC4=C(NN=C4)C(C)=C3)=O)CC2)OC5=CC(C)=C(C)C=C15
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)