1. Membrane Transporter/Ion Channel Metabolic Enzyme/Protease
  2. Monocarboxylate Transporter Mitochondrial Metabolism
  3. 7ACC2

7ACC2 

Cat. No.: HY-D0713 Purity: 99.62%
COA Handling Instructions

7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux.

For research use only. We do not sell to patients.

7ACC2 Chemical Structure

7ACC2 Chemical Structure

CAS No. : 1472624-85-3

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO USD 102 In-stock
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5 mg USD 90 In-stock
10 mg USD 150 In-stock
50 mg USD 512 In-stock
100 mg USD 820 In-stock
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    7ACC2 purchased from MedChemExpress. Usage Cited in: OncoImmunology. 2022 Dec 22;12(1):2160558.  [Abstract]

    7ACC2 (100 nM; 7 days) decreases H3K18la levels in NKT-like cells.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux[1][2].

    IC50 & Target

    IC50: 11 nM (Monocarboxylate transporter)[1]
    Mitochondrial pyruvate transport[2]

    In Vitro

    7ACC2 (compound 19; 72 hours) inhibits SiHa cells proliferation in lactate-containing medium with an EC50 of 0.22 μM. In SiHa cells, lactate uptake primarily depends on the high affinity MCT1 transporter[1].
    7ACC2 (compound 19) shows an excellent chemical stability in simulated gastric (SGF) and intestinal (SIF) fluids, a good apparent permeability coefficient (Papp) through Caco-2 monolayer and a high metabolic stability on mouse (MLM) and human liver microsomes (HLM) as well as on human hepatocytes[1].
    7ACC2 is a potent inhibitor of mitochondrial pyruvate transport which consecutively blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    7ACC2 (3 mg/kg; intraperitoneal administration; daily; for 5 days or 10days) treatment significantly inhibits tumor growth in mice. 7ACC2 radiosensitizes tumor cells by reducing hypoxia in vivo[2].
    The intraperitoneal administration of 7ACC2 (compound 19; 3 mg/kg) to mice leads to a Cmax of 1246 ng/ml (4 μM) in a very short time (Tmax=10 min) associated with a plasma half-life of 4.5 h[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 7-week-old female NMRI nude mice with radiotherapy administered[2]
    Dosage: 3 mg/kg
    Administration: Intraperitoneal administration; daily; for 5 days or 10days
    Result: A significant increase in tumor growth delay was observed.
    Molecular Weight

    309.32

    Formula

    C18H15NO4

    CAS No.
    Appearance

    Solid

    Color

    Light yellow to yellow

    SMILES

    CN(C1=CC=C(C=C(C(O)=O)C(O2)=O)C2=C1)CC3=CC=CC=C3

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (161.64 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2329 mL 16.1645 mL 32.3290 mL
    5 mM 0.6466 mL 3.2329 mL 6.4658 mL
    10 mM 0.3233 mL 1.6164 mL 3.2329 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.5 mg/mL (8.08 mM); Suspended solution; Need ultrasonic

    *All of the co-solvents are available by MedChemExpress (MCE).
    Purity & Documentation
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    7ACC2
    Cat. No.:
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