1. Signaling Pathways
  2. Membrane Transporter/Ion Channel
  3. Monocarboxylate Transporter
  4. MCT1 Isoform

MCT1

Monocarboxylate transporter 1 (MCT1) also known as solute carrier family 16 member 1 (SLC16A1). The major physiological role of MCT1 is to facilitate lactic acid entry into or efflux out of cells depending on their metabolic state. In liver parenchymal cells and the proximal convoluted tubule cells of the kidney, MCT1 may be used to transport L-lactate into the cells for gluconeogenesis for which it is a major substrate, especially after exercise. In the heart and red skeletal muscle, MCT1 is required for lactate and ketone bodies to enter the myocytes and be oxidized as a major respiratory fuel under conditions when their concentrations are elevated. Indeed, in skeletal muscle, there is a strong correlation between the amount of MCT1 expressed in muscle fibers and their oxidative capacity (mitochondrial content.MCT1 also facilitates the transport of these same monocarboxylates across the blood brain barrier for uptake into neurons (via MCT1 or MCT2) which, like red skeletal muscle, use them as respiratory fuels. In both muscle and the brain, there is cooperation between MCT isoforms involved in lactic acid efflux and influx by different cell types within the same tissue.

MCT1 Related Products (4):

Cat. No. Product Name Effect Purity
  • HY-12750
    AZD3965
    Inhibitor 99.95%
    AZD3965 is a selective MCT1 inhibitor with a Ki of 1.6 nM, showing 6-fold selectivity over MCT2.
  • HY-13248
    AR-C155858
    Inhibitor 99.62%
    AR-C155858 is a selective monocarboxylate transporter MCT1 and MCT2 inhibitor with Kis of 2.3 nM and 10 nM, respectively.
  • HY-N4115
    Syrosingopine
    Inhibitor 99.30%
    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine.
  • HY-122312
    BAY-8002
    Inhibitor 98.39%
    BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.