Art. -Nr.: HY-D0067

7ACC1

(Synonyms: DEAC; Coumarin D 1421; D 1421)

10 Cited Publications

Kundenbewertung

Based on 10 publication(s) in Google Scholar

7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation, migration, invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers.

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Reinheit: 99.94%
CAS. Nr.: 50995-74-9
Formel: C₁₄H₁₅NO₄
Molecular Weight:261.27

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

7ACC1 Chemical Structure

CAS. Nr.: 50995-74-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Emission (Em)
- Excitation (Ex)
Chemical Information
Publications (10)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

MCT1

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	>100 μM Compound: 7	Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against mouse 4T1 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 34626786]
HepG2	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay	[PMID: 28666736]
MCF-10A	IC₅₀	>100 μM Compound: 7	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 34626786]
MCF7	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay	[PMID: 28666736]
MDA-MB-231	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTT assay	[PMID: 28666736]
MDA-MB-231	IC₅₀	>100 μM Compound: 7	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 34626786]
MDA-MB-231	IC₅₀	>50 μM Compound: 11	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 48 hrs by MTT assay	[PMID: 37602711]
SiHa	EC₅₀	1.8 μM Compound: 17	Cytotoxicity against human SiHa cells in lactate-containing medium after 72 hrs by MTT assay Cytotoxicity against human SiHa cells in lactate-containing medium after 72 hrs by MTT assay	[PMID: 24095010]
SiHa	IC₅₀	0.86 μM Compound: 17	Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 24 hrs by liquid scintillation counting	[PMID: 24095010]
SiHa	IC₅₀	250 nM Compound: 17	Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting Inhibition of MCT4-mediated [14C]-lactate uptake in human SiHa cells in lactate-containing medium assessed as remaining lactate concentration in culture medium after 12 mins by liquid scintillation counting	[PMID: 24095010]
SK-HEP1	IC₅₀	>100 μM Compound: 10	Antiproliferative activity against human SKHEP1 cells after 48 hrs by MTT assay Antiproliferative activity against human SKHEP1 cells after 48 hrs by MTT assay	[PMID: 28666736]
WiDr	IC₅₀	>100 μM Compound: 7	Antiproliferative activity against human WiDr cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human WiDr cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 34626786]

In Vitro

7ACC1 (10 μM, 0-96 h) attenuates the viability, decreases cell migration and invasion in co-culturing conditions of 786-O cells and HUVECs^[1].
7ACC1 (10 μM, 24 h) inhibits the protein expressions of MCT1 and MCT4, down-regulates the extracellular lactate levels in co-culturing conditions of 786-O cells and HUVECs^[1].
7ACC1 (0-1 μM, 24 h) inhibit the influx but not the efflux of lactate in cancer cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

786-O cells and HUVECs
Concentration:

10 µM
Incubation Time:

24 h
Result:

Attenuated the protein expressions of MCT1 and MCT4 in co-culturing of 786-O cells and HUVECs.

In Vivo

7ACC1 (3 mg/kg, i.p., daily for 12 days) inhibits the growth of MCT-expressing cervix SiHa, colorectal HCT116 and breast MCF-7 tumors in mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

mice bearing tumors, including cervix cancer SiHa xenografts but also tumors derived from human colon cancer cells HCT116 and bladder cancer cells UM-UC3^[2]
Dosage:

3 mg/kg
Administration:

i.p., daily for 12 days
Result:

Led to significant SiHa and HCT116 tumor growth delays in mice bearing tumors.

Emission (Em)

445

Excitation (Ex)

345

Chemical Information

CAS. Nr. 50995-74-9
Appearance Solid
Molecular Weight 261.27
Formel C₁₄H₁₅NO₄
Color Orange to red
SMILES

O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)O
Synonyms

DEAC; Coumarin D 1421; D 1421
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (10)

All WB

Sort by:

Journal Impact Factor

Cell Metab

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy. [Abstract]

2021 Oct 5;33(10):2021-2039.e8. PMID: 34508696
Microbiome

Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders. [Abstract]

2022 Dec 15;10(1):226. PMID: 36517893
Cancer Cell Int

Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. [Abstract]

2019 Jun 28:19:170. PMID: 31297034
J Biol Chem

Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice. [Abstract]

2022 Feb;298(2):101554. PMID: 34973337
Exp Cell Res

ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer. [Abstract]

2022 Mar 15;412(2):113044. PMID: 35093305
Cancer Med

Downregulation of MCT4 for lactate exchange promotes the cytotoxicity of NK cells in breast carcinoma. [Abstract]

2018 Sep;7(9):4690-4700. PMID: 30051648

7ACC1 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2018 Sep;7(9):4690-4700. [Abstract]

The protein expression of MCT4 in the murine breast cancer cell line 4T1 treated with 7ACC1 (0.1 mM) or transfected with different ShMCT4 vectors.
Aesthetic Plast Surg

Poly-L-Lactic Acid Reduces the Volume of Dermal Adipose Tissue Through its Metabolite Lactate. [Abstract]

2024 Dec;48(23):5136-5146. PMID: 39060798
bioRxiv

2026 Mar 10.
J Oncol

MCT4/Lactate Promotes PD-L1 Glycosylation in Triple-Negative Breast Cancer Cells. [Abstract]

2022 Sep 26;2022:3659714. PMID: 36199799
Research Square Preprint

2021 Aug.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 33.33 mg/mL (127.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.8275 mL

19.1373 mL

38.2746 mL

5 mM

0.7655 mL

3.8275 mL

7.6549 mL

10 mM

0.3827 mL

1.9137 mL

3.8275 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Guo C, et al. Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. Cancer Cell Int. 2019 Jun 28;19:170. [Content Brief]

[2]. Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8. [Content Brief]

[3]. Mohamed F A, et al. Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction[J]. Blood, 2023, 142: 459.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.8275 mL	19.1373 mL	38.2746 mL	95.6865 mL
	5 mM	0.7655 mL	3.8275 mL	7.6549 mL	19.1373 mL
	10 mM	0.3827 mL	1.9137 mL	3.8275 mL	9.5686 mL
	15 mM	0.2552 mL	1.2758 mL	2.5516 mL	6.3791 mL
	20 mM	0.1914 mL	0.9569 mL	1.9137 mL	4.7843 mL
	25 mM	0.1531 mL	0.7655 mL	1.5310 mL	3.8275 mL
	30 mM	0.1276 mL	0.6379 mL	1.2758 mL	3.1895 mL
	40 mM	0.0957 mL	0.4784 mL	0.9569 mL	2.3922 mL
	50 mM	0.0765 mL	0.3827 mL	0.7655 mL	1.9137 mL
	60 mM	0.0638 mL	0.3190 mL	0.6379 mL	1.5948 mL
	80 mM	0.0478 mL	0.2392 mL	0.4784 mL	1.1961 mL
	100 mM	0.0383 mL	0.1914 mL	0.3827 mL	0.9569 mL

7ACC1

10 Cited Publications

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7ACC1

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Targeted Diversity Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) 7ACC1

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

7ACC1

Membrane Transporter/Ion Channel Compound Library

Anti-Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Targeted Diversity Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Bioactive Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) 7ACC1

Alle Monocarboxylate Transporter Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (10)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

7ACC1 Related Classifications

HY-D0067 Related Classifications