1. Membrane Transporter/Ion Channel
  2. Monocarboxylate Transporter
  3. 7ACC1

7ACC1 (Synonyms: DEAC; Coumarin D 1421; D 1421)

Cat. No.: HY-D0067 Purity: 99.66%
Handling Instructions

7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters.

For research use only. We do not sell to patients.

7ACC1 Chemical Structure

7ACC1 Chemical Structure

CAS No. : 50995-74-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
100 mg USD 102 In-stock
Estimated Time of Arrival: December 31
200 mg USD 162 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
1 g   Get quote  

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Customer Review

Based on 3 publication(s) in Google Scholar

Top Publications Citing Use of Products

    7ACC1 purchased from MCE. Usage Cited in: Cancer Med. 2018 Sep;7(9):4690-4700.

    The protein expression of MCT4 in the murine breast cancer cell line 4T1 treated with 7ACC1 (0.1 mM) or transfected with different ShMCT4 vectors.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. IC50 value: 0.86 uM(Lactate uptake inhibition) [1] Target: MCT inhibitor; lactate transport inhibitor Contrary to the reference MCT1 inhibitor AR-C155858, 7ACC unexpectedly inhibited lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. 7ACC delayed the growth of cervix SiHa tumors, colorectal HCT116 tumors, and orthoptopic MCF-7 breast tumors. MCT target engagement was confirmed by the lack of activity of 7ACC on bladder UM-UC-3 carcinoma that does not express functional MCT. 7ACC also inhibited SiHa tumor relapse after treatment with cisplatin. Finally, we found that contrary to AR-C155858, 7ACC did not prevent the cell entry of the substrate-mimetic drug 3-bromopyruvate (3BP) through MCT1, and contributed to the inhibition of tumor relapse after 3BP treatment.

    Storage

    4°C, protect from light

    Solvent & Solubility
    In Vitro: 

    DMSO : 32 mg/mL (122.48 mM; Need ultrasonic and warming)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.8275 mL 19.1373 mL 38.2746 mL
    5 mM 0.7655 mL 3.8275 mL 7.6549 mL
    10 mM 0.3827 mL 1.9137 mL 3.8275 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    261.27

    Formula

    C₁₄H₁₅NO₄

    CAS No.

    50995-74-9

    SMILES

    O=C(C1=CC2=CC=C(N(CC)CC)C=C2OC1=O)O

    Shipping

    Room temperature in continental US; may vary elsewhere

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    × = ×
    C1   V1   C2   V2

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    Product Name:
    7ACC1
    Cat. No.:
    HY-D0067
    Quantity:

    7ACC1

    Cat. No.: HY-D0067