1. Membrane Transporter/Ion Channel
  2. Monocarboxylate Transporter

BAY-8002 

Cat. No.: HY-122312
Handling Instructions

BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity.

For research use only. We do not sell to patients.

BAY-8002 Chemical Structure

BAY-8002 Chemical Structure

CAS No. : 724440-27-1

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BAY-8002 is a potent, selective, orally active inhibitor of monocarboxylate transporter 1 (MCT1), with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4. Anti-tumor activity[1].

IC50 & Target

IC50: 85 nM (MCT1, in DLD-1 cells)[1]

In Vitro

BAY-8002 is an inhibitor of MCT1, with an IC50 of 85 nM in the MCT1-expressing DLD-1 cells, displays excellent selectivity against MCT4 (IC50 >50 µM in EVSA-T cells)[1].

In Vivo

BAY-8002 (80 and 160 mg/kg, p.o., twice daily, for more than 26 days) significantly inhibits tumor growth in Raji tumor-bearing mice[1].

Animal Model: Female NOD SCID mice bearing Raji cells (7-10 weeks old)[1]
Dosage: 80 and 160 mg/kg
Administration: P.O. twice daily for more than 26 days
Result: Inhibited tumor growth with no obvious body weight loss, but showed no effect on tumor regression.
References
Molecular Weight

415.85

Formula

C₂₀H₁₄ClNO₅S

CAS No.

724440-27-1

SMILES

O=C(O)C1=CC=CC=C1NC(C2=CC(S(=O)(C3=CC=CC=C3)=O)=CC=C2Cl)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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BAY-8002
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HY-122312
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BAY-8002

Cat. No.: HY-122312