2. Membrane Transporter/Ion Channel
  3. Monocarboxylate Transporter
  4. Syrosingopine

Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine.

For research use only. We do not sell to patients.

CAS No. : 84-36-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Customer Review

Based on 13 publication(s) in Google Scholar

Other Forms of Syrosingopine:

Syrosingopine Related Antibodies

Top Publications Citing Use of Products

    Syrosingopine purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 31;10(1):356.  [Abstract]

    ATP and extracellular lactate were tested in PAMC82 and SNU16 cells treated with Metformin (MET; 10 μM, 48 h) and/or Syrosingopine (Syro; 20 μM, 48 h).

    Syrosingopine purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 31;10(1):356.  [Abstract]

    Protein expression related to the PI3K/AKT and AMPK/mTOR pathways was tested in PAMC82 and SNU16 cells treated with Metformin and/or Syrosingopine (20 μM). The synergistic inhibition of cell proliferation.

    Syrosingopine purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Oct 31;10(1):356.  [Abstract]

    The combination of MET and Syrosingopine (SYRO) (20 μM) inhibited the migration in PAMC82 and SNU16 cells.

    Syrosingopine purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2023 Jun;11(6):e006287.  [Abstract]

    Syrosingopine (1.25, 2.5, 5, 10, 20 μM, 48 h) significantly reduced IFN-γ production in a dose-dependent manner by ELISA.

    Syrosingopine purchased from MedChemExpress. Usage Cited in: J Immunother Cancer. 2023 Jun;11(6):e006287.  [Abstract]

    Syrosingopine (1.25, 2.5, 5, 10, 20 μM) alone reduced the number of tumor cells.

    View All Monocarboxylate Transporter Isoform Specific Products:

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    MCT1 MCT2 MCT4

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine[1][2].

    IC50 & Target

    MCT1

     

    MCT4

     

    In Vitro

    Syrosingopine (10 μM; 1, 3, 4 hours) causes accumulation of intracellular lactate after 1 hour and peaks at 4 hours, which lead to intracellular acidification in HeLa cells[1].
    Syrosingopine (10 μM; 1, 2 hours) slows lactate efflux by inhibiting MCT4 and MCT1 in MCT1-KO and MCT4-KO HAP1 cells, respectively[1].
    Syrosingopine (10-100 μM)-metformin combination induces synthetic lethality by inhibiting transport of lactate in HAP1 MCT1-KO cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Syrosingopine Related Antibodies

    Cell Viability Assay[1]

    Cell Line: HeLa, MCT1-KO, MCT4-KO HAP1, HAP1 MCT1-KO
    Concentration: 10 µM
    Incubation Time: 1, 2, 3, 4 hours
    Result: Caused intracellular lactate accumulation and acidification.
    Slowed lactate efflux by inhibiting MCT4 and MCT1.
    Induced synthetic lethality by inhibiting transport of lactate when combined with metformin.
    In Vivo

    Syrosingopine (5 mg/kg; s.c.; once) shows anti-hypertensive activity which as low as the result after ganglionic blockade by depleting peripheral stores of norepinephrine[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Spontaneously hypertensive rats (SHR) (2 to 17-month-age)[2].
    Dosage: 5 mg/kg
    Administration: Subcutaneous injection; once (16 hours before undertaking the study of blood pressure).
    Result: Showed anti-hypertensive activity by depleting peripheral stores of norepinephrine.
    Molecular Weight

    666.71

    Formula

    C35H42N2O11
    CAS No.
    Appearance

    Solid

    Color

    White to yellow

    SMILES

    [H][C@@]12C(NC3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 62.5 mg/mL (93.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4999 mL 7.4995 mL 14.9990 mL
    5 mM 0.3000 mL 1.4999 mL 2.9998 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (3.12 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    % 
    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.52%

    SDS (393 KB)

    COA (250 KB) HNMR (297 KB) RP-HPLC (247 KB) MS (69 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.4999 mL 7.4995 mL 14.9990 mL 37.4976 mL
    5 mM 0.3000 mL 1.4999 mL 2.9998 mL 7.4995 mL
    10 mM 0.1500 mL 0.7500 mL 1.4999 mL 3.7498 mL
    15 mM 0.1000 mL 0.5000 mL 0.9999 mL 2.4998 mL
    20 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8749 mL
    25 mM 0.0600 mL 0.3000 mL 0.6000 mL 1.4999 mL
    30 mM 0.0500 mL 0.2500 mL 0.5000 mL 1.2499 mL
    40 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9374 mL
    50 mM 0.0300 mL 0.1500 mL 0.3000 mL 0.7500 mL
    60 mM 0.0250 mL 0.1250 mL 0.2500 mL 0.6250 mL
    80 mM 0.0187 mL 0.0937 mL 0.1875 mL 0.4687 mL
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    Syrosingopine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Syrosingopine84-36-6Su 3118Su3118Su-3118Monocarboxylate TransporterglycolysisMCTslactatesynthetic lethalityNAD+metformincancerInhibitorinhibitorinhibit

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