84-36-6
84-36-6
Chemical Structure
Syrosingopine
Synonym(s): Su 3118
- CAS No.: 84-36-6
- Formula:C35H42N2O11
- Molecular Weight:666.71
IUPAC Name: methyl (1S,2R,3R,4aS,13bR,14aS)-3-((4-((ethoxycarbonyl)oxy)-3,5-dimethoxybenzoyl)oxy)-2,11-dimethoxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate
InChIKey: ZCDNRPPFBQDQHR-SSYATKPKSA-N
SMILES: [H][C@@]12C(NC3=C4C=CC(OC)=C3)=C4CCN1C[C@]5(C[C@@H](OC(C6=CC(OC)=C(OC(OCC)=O)C(OC)=C6)=O)[C@H](OC)[C@@H](C(OC)=O)[C@]5(C2)[H])[H]
Biological Activity: Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Syrosingopine | 99.52% | Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine. | ||||||||||||||||||||
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Syrosingopine (Standard) | ≥98% | Syrosingopine (Su 3118) is an orally active lactate transporters (MCT1/MCT4) dual inhibitor, which can reduce glycolysis and induce synthetic lethality in cancer cells when combine with metformin. Syrosingopine shows anti-hypertensive activity by depleting peripheral stores of norepinephrine. | ||||||||||||||||||||
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Deserpidine hydrochloride | Deserpidine hydrochloride (Harmonyl hydrochloride) is an antihypertensive compound that competitively inhibits the activity of angiotensin converting enzyme (ACE). Deserpidine hydrochloride competes with angiotensin I for ACE, preventing the conversion of angiotensin I to angiotensin II, thereby lowering blood pressure. Deserpidine hydrochloride can also reduce angiotensin II-induced aldosterone secretion from the adrenal cortex. | |||||||||||||||||||||
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Deserpidine (Standard) | ≥98% | Deserpidine (Standard) is the analytical standard of Deserpidine. This product is intended for research and analytical applications. Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex. | ||||||||||||||||||||
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Methyl reserpate | Methyl reserpate (NSC 81464) is a Yohimbine (HY-12715) type alkaloid that can be isolated from Rauwolfia vomitoria roots and leaves. | |||||||||||||||||||||
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Metoserpate hydrochloride | Metoserpate hydrochloride is a reserpine-type sedative for poultry. Metoserpate hydrochloride reduces fear-related tonic immobility responses in chicks, inhibits neonatal imprinting approach behavior in an age-dependent manner, and controls hysteria in pullet flocks after administration via drinking water. Metoserpate hydrochloride can be used in studies related to avian fear, stress, imprinting learning and behavioral regulation. | |||||||||||||||||||||
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Methoserpidine | Methoserpidine is an active compound. | |||||||||||||||||||||
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Bishomoreserpine | Bishomoreserpine is a reserpine analog with potent inhibitory effect. | |||||||||||||||||||||
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Rescinnamine | 95.83% | Rescinnamine is a derivative of the indole alkaloid reserpine. Rescinnamine shows sedative effects. Rescinnamine can be used for hypertension research. | ||||||||||||||||||||
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Reserpine | 99.92% | Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
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Reserpine hydrochloride (Standard) | ≥98% | Reserpine (hydrochloride) (Standard) is the analytical standard of Reserpine (hydrochloride). This product is intended for research and analytical applications. Reserpine hydrochloride is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
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Reserpine-d9 | 96.84% | Reserpine-d9 is the deuterium labeled Reserpine. Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). | ||||||||||||||||||||
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References
- [1]. Benjamin D, et al. Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells. Cell Rep. 2018 Dec 11;25(11):3047-3058.e4. [Content Brief]
- [2]. Lefèvre-Borg F, et al. Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension. 1988 Apr;11(4):360-70. [Content Brief]
