227321-12-2
227321-12-2
Chemical Structure
MCT1-IN-2
- CAS No.: 227321-12-2
- Formula:C25H29N3O2S
- Molecular Weight:435.58
IUPAC Name: 7-((3-hydroxypropyl)thio)-4-isobutyl-2-methyl-6-(naphthalen-1-ylmethyl)-2,6-dihydro-1H-pyrrolo[3,4-d]pyridazin-1-one
InChIKey: VDAVMXLEMHVXOG-UHFFFAOYSA-N
SMILES: O=C1C2=C(SCCCO)N(CC3=C4C=CC=CC4=CC=C3)C=C2C(CC(C)C)=NN1C
Biological Activity: MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MCT1-IN-2 | 99.88% | MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.47
HY-1683345-HT2C agonist-4 -
Similarity Score 0.44
HY-143906URAT1 inhibitor 2 -
Similarity Score 0.44
HY-19687Zopolrestat -
Similarity Score 0.43
HY-106697RPonalrestat (Standard) -
Similarity Score 0.43
HY-W7483621-(1-Methyl-1H-indol-3-yl)-2-(1-naphthalenyl)ethanone -
Similarity Score 0.43
HY-147705PPARγ phosphorylation inhibitor 1 -
Similarity Score 0.43
HY-124487GK-136901 -
Similarity Score 0.43
HY-19148A7U85 hydrochloride -
Similarity Score 0.43
HY-143235BRD4 Inhibitor-15 -
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References
- [1]. Clare M Murray, et al. Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol. 2005 Dec;1(7):371-6. [Content Brief]
- [2]. Hui Wang, et al. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J Med Chem. 2014 Sep 11;57(17):7317-24. [Content Brief]
