1. Metabolic Enzyme/Protease
  2. Aldose Reductase
  3. Zopolrestat

Zopolrestat (Synonyms: CP73850)

Cat. No.: HY-19687
Handling Instructions

Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications.

For research use only. We do not sell to patients.

Zopolrestat Chemical Structure

Zopolrestat Chemical Structure

CAS No. : 110703-94-1

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Description

Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications[1].

In Vitro

Zopolrestat is a potent inhibitor of the reduction of both glyceraldehyde and glucose by the human and rat enzymes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Zopolrestat (2.5 mg/kg-50 mg/kg; p.o.; once-a-day for 5 days) and left untreated for 7 days) prevents accumulation of sorbitol in the kidney cortex of diabetic rats and normalize elevated renal blood flow in galactosemic rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats (made diabetic by iv injection of streptozotocin)[1].
Dosage: 2.5 mg/kg-50 mg/kg
Administration: P.o.; once-a-day for 5 days
Result: Its ED50s in reversing already elevated sorbitol accumulation in rat sciatic nerve, retina, and lens in a chronic test were 1.9, 17.6, and 18.4 mg/kg, respectively.
Molecular Weight

419.38

Formula

C₁₉H₁₂F₃N₃O₃S

CAS No.
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Zopolrestat
Cat. No.:
HY-19687
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