2. Others Metabolic Enzyme/Protease
  3. Reference Standards Aldose Reductase
  4. Ponalrestat (Standard)

Ponalrestat (Standard)  (Synonyms: ICI 128436 (Standard))

Cat. No.: HY-106697R
Handling Instructions Technical Support

Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol.

For research use only. We do not sell to patients.

Ponalrestat (Standard)

Ponalrestat (Standard) Chemical Structure

CAS No. : 72702-95-5

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Ponalrestat (Standard) Related Antibodies

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Description

Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol[1][2][3].

IC50 & Target

Ki: 7.7 nM (ALR2) and 60 μM (ALR1)[1]
Molecular Weight

391.19

Formula

C17H12BrFN2O3
CAS No.
SMILES

OC(CC(C1=C2C=CC=C1)=NN(CC3=C(C=C(Br)C=C3)F)C2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ponalrestat (Standard) Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ponalrestat (Standard)72702-95-5ICI 128436 (Standard)Reference StandardsAldose ReductaseorallynoncompetitiveAKR1B1ALRALR2ALR1conversionglucosesorbitolInhibitorinhibitorinhibit

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