72702-95-5
72702-95-5
Chemical Structure
Ponalrestat
Synonym(s): ICI 128436
- CAS No.: 72702-95-5
- Formula:C17H12BrFN2O3
- Molecular Weight:391.19
IUPAC Name: 2-(3-(4-bromo-2-fluorobenzyl)-4-oxo-3,4-dihydrophthalazin-1-yl)acetic acid
InChIKey: LKBFFDOJUKLQNY-UHFFFAOYSA-N
SMILES: OC(CC(C1=C2C=CC=C1)=NN(CC3=C(C=C(Br)C=C3)F)C2=O)=O
Biological Activity: Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Ponalrestat | 99.35% | Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Ponalrestat (Standard) | Ponalrestat (Standard) (ICI 128436 (Standard)) is the analytical standard of Ponalrestat (HY-106697). This product is intended for research and analytical applications. Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 μM). Ponalrestat inhibits the conversion of glucose to sorbitol. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
AF-2785 | AF-2785 is a potent CFTR blocker. AF-2785 inhibits the cAMP-activated chloride current in rat epididymal cells with an IC50 of 170.6 μM. AF-2785 can be used in research related to contraceptives. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Tolnidamine | Tolnidamine is an orally active sperm production inhibitor. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Talastine hydrochloride | Talastine hydrochloride is an antihistamine with antiallergic activity. Talastine hydrochloride is used to relieve allergic symptoms. Talastine hydrochloride may cause adverse reactions such as rash, indicating differences in individual sensitivity. Talastine hydrochloride is considered a potential option for inhibiting allergic reactions. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Enpp-1-IN-19 | 99.28% | Enpp-1-IN-19 (compound 29f) is an orally active ENPP1 inhibitor that inhibits cGAMP hydrolysis by ENPP1 (IC50=68 nM). Enpp-1-IN-19 increases anti-PD-L1 responses and inhibits tumor growth in CT26 syngeneic models. Enpp-1-IN-19 also enhances STING-mediated type I interferon responses, induces immune memory, and prevents tumor recurrence. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
PARP1 ligand-1 | PARP1 ligand-1 is a PARP1 ligand, which can be used for the synthesis of PROTACs, such as CW-2 (HY-173437). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Zopolrestat | 99.69% | Zopolrestat (CP73850) is a potent, orally active aldose reductase (AR) inhibitor with an IC50 of 3.1 nM. Zopolrestat is used for the research of diabetic complications. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Lonidamine | 99.91% | Lonidamine (AF-1890) is a hexokinase and mitochondrial pyruvate carrier inhibitor (Ki: 2.5 μM). Lonidamine also inhibits aerobic glycolysis in cancer cells. Lonidamine can be used in the research of mitochondrial metabolism and inflammation, such as pulmonary fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Vericiguat impurity-1 | Vericiguat impurity-1 is the impurity of Vericiguat (HY-16774). Vericiguat impurity-1 can be used as impurity standards in impurity analysis, to develop selective and quantitative methods to determine impurities. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Talastine | 99.84% | Talastine is a potent H1-antihistamine. Talastine can induce allergic exanthema. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Olaparib impurity 22 | Olaparib impurity 22 is an impurity of Olaparib (HY-10162). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Ward WH, et al. Ponalrestat: a potent and specific inhibitor of aldose reductase. Biochem Pharmacol. 1990 Jan 15;39(2):337-46. [Content Brief]
- [2]. Bresson E, et al. The human aldose reductase AKR1B1 qualifies as the primary prostaglandin F synthase in the endometrium. J Clin Endocrinol Metab. 2011 Jan;96(1):210-9. [Content Brief]
- [3]. Calcutt NA, et al. Prevention of sensory disorders in diabetic Sprague-Dawley rats by aldose reductase inhibition or treatment with ciliary neurotrophic factor. Diabetologia. 2004 Apr;47(4):718-24. [Content Brief]
