BRD4 Inhibitor-15
BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2761366-60-1
- Formula: C22H21N3O2
- Molecular Weight:359.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Caspase Isoforms
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Biological Activity
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BRD4(1) 18 ± 1.1 nM (IC50) |
Bcl-2 |
Bax |
Caspase-3 |
Procaspase-3 |
BRD4 Inhibitor-15 (compound 13) shows potent anti-proliferative activity against enzalutamide-resistant 22RV1 cells and LNCap cells, with IC50 values of 8.27 ± 0.28 and 7.33 ± 0.49 μM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2761366-60-1
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Molecular Weight 359.42
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Formula C22H21N3O2
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SMILES
CCOC1=CC(N(C=C1C2=CC3=C(C=NN3CC4=CC=CC=C4)C=C2)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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