2761366-60-1
2761366-60-1
Chemical Structure
BRD4 Inhibitor-15
- CAS No.: 2761366-60-1
- Formula:C22H21N3O2
- Molecular Weight:359.42
IUPAC Name: 5-(1-benzyl-1H-indazol-6-yl)-4-ethoxy-1-methylpyridin-2(1H)-one
InChIKey: GWTFQNZDRCSCTL-UHFFFAOYSA-N
SMILES: CCOC1=CC(N(C=C1C2=CC3=C(C=NN3CC4=CC=CC=C4)C=C2)C)=O
Biological Activity: BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research[1].
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BRD4 Inhibitor-15 | BRD4 Inhibitor-15 (compound 13) is a potent BRD4 inhibitor, with an IC50 of 18 nM. BRD4 Inhibitor-15 induces apoptosis of 22RV1 cells by regulating Bcl-2/Bax proteins and activating caspase-3 signaling pathway. BRD4 Inhibitor-15 down-regulates the c-Myc level in 22RV1 cells. BRD4 Inhibitor-15 can be used for prostate cancer research. | |||||||||||||||||||||
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