1. Metabolic Enzyme/Protease
  2. Acetyl-CoA Carboxylase
  3. CMS-121

CMS-121 

Cat. No.: HY-135981
Handling Instructions

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities.

For research use only. We do not sell to patients.

CMS-121 Chemical Structure

CMS-121 Chemical Structure

CAS No. : 1353224-53-9

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Description

CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].

IC50 & Target

Acetyl-CoA carboxylase 1 (ACC1)[1]

In Vitro

CMS-121 (1 µM; 4 hours; HT22 cells) treatment increases the phosphorylation of ACC1 at serine 79. CMS-121 can increase acetyl-CoA in cells[1].

Western Blot Analysis[1]

Cell Line: HT22 cells
Concentration: 1 µM
Incubation Time: 4 hours
Result: Increases the phosphorylation of ACC1 at serine 79.
In Vivo

CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1].

Animal Model: Female SAMP8 mice (9 months old)[1]
Dosage: ~20 mg/kg/day
Administration: Oral administration; daily; for 4 months
Result: Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain.
Molecular Weight

321.37

Formula

C₂₀H₁₉NO₃

CAS No.

1353224-53-9

SMILES

OC1=CC=C(C2=NC3=CC=CC=C3C(OC4CCCC4)=C2)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CMS-121CMS121CMS 121Acetyl-CoA CarboxylaseACC, Acetyl Coenzyme A CarboxylaseACC1Alzheimer'sdiseasedementianeuroprotectivemitochondrialH3K9anti-inflammatoryacetylationantioxidativeInhibitorinhibitorinhibit

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CMS-121
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HY-135981
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