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UQCRB - ubiquinol-cytochrome c reductase binding protein Gene

Also Known as QPC; QCR7; QP-C; UQBC; UQBP; UQPC; UQCR6; MC3DN3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7381

About UQCRB

Cytogenetic location: 8q22.1 Genomic coordinates (GRCh38): 8:96,222,947-96,235,545 (from NCBI)

This gene has 9 transcripts (splice variants), 273 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 51.3), kidney (RPKM 32.2) and 25 other tissues.

Summary

This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]

UQCRB Products (3)

mRNA	Protein	Name
NM_001199975.3	NP_001186904.1	cytochrome b-c1 complex subunit 7 isoform 2
NM_001254752.2	NP_001241681.1	cytochrome b-c1 complex subunit 7 isoform 3
NM_006294.5	NP_006285.1	cytochrome b-c1 complex subunit 7 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UQCRB Protein Structure

UCR_14kD

0
100
111 a.a.

Protein Preferred Names	Protein Names
cytochrome b-c1 complex subunit 7	complex III subunit 7

UQCRB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UQCRB	P14927	MAGEA4	Homo sapiens	Q1RN33	Y2H Array	25416956
Intra	UQCRB	P14927	MAGEA4	Homo sapiens	Q1RN33	Y2H Prey Pooling	25416956
Intra	UQCRB	P14927	LARP4B	Homo sapiens	Q92615	Y2H Pooling	32814053
Intra	UQCRB	P14927	LARP4B	Homo sapiens	Q92615	Validated Y2H	32814053
Intra	UQCRB	P14927	LARP4B	Homo sapiens	Q92615	Y2H Array	32814053
Intra	UQCRB	P14927	FYN	Homo sapiens	P06241-3	Validated Y2H	32814053
Intra	UQCRB	P14927	FYN	Homo sapiens	P06241-3	Y2H Array	32814053
Intra	UQCRB	P14927	FYN	Homo sapiens	P06241-3	Y2H Pooling	32814053
Intra	UQCRB	P14927	HPCA	Homo sapiens	P84074	Validated Y2H	32296183
Intra	UQCRB	P14927	CYC1	Homo sapiens	P08574	Anti Tag CoIP	33961781
Intra	UQCRB	P14927	THAP3	Homo sapiens	Q8WTV1	Validated Y2H	32814053
Intra	UQCRB	P14927	THAP3	Homo sapiens	Q8WTV1	Y2H Array	32814053
Intra	UQCRB	P14927	THAP3	Homo sapiens	Q8WTV1	Y2H Pooling	32814053
Intra	UQCRB	P14927	DPP9	Homo sapiens	Q86TI2-2	Y2H Pooling	32814053
Intra	UQCRB	P14927	DPP9	Homo sapiens	Q86TI2-2	Validated Y2H	32814053
Intra	UQCRB	P14927	DPP9	Homo sapiens	Q86TI2-2	Y2H Array	32814053
Intra	UQCRB	P14927	KIAA0355	Homo sapiens	A1A512	Validated Y2H	32814053
Intra	UQCRB	P14927	KIAA0355	Homo sapiens	A1A512	Y2H Array	32814053
Intra	UQCRB	P14927	KIAA0355	Homo sapiens	A1A512	Y2H Pooling	32814053
Intra	UQCRB	P14927	ZSWIM7	Homo sapiens	Q19AV6	Validated Y2H	32296183
Intra	UQCRB	P14927	ITGB3BP	Homo sapiens	Q13352	Y2H Pooling	32814053
Intra	UQCRB	P14927	ITGB3BP	Homo sapiens	Q13352	Validated Y2H	32814053
Intra	UQCRB	P14927	ITGB3BP	Homo sapiens	Q13352	Y2H Array	32814053
Intra	UQCRB	P14927	MAGEA4	Homo sapiens	P43358	Validated Y2H	32296183
Intra	UQCRB	P14927	MAGEA4	Homo sapiens	P43358	Y2H Array	32296183
Intra	UQCRB	P14927	MAGEA4	Homo sapiens	P43358	Y2H Prey Pooling	32296183
Intra	UQCRB	P14927	ACCS	Homo sapiens	Q96QU6	Validated Y2H	25416956
Intra	UQCRB	P14927	ACCS	Homo sapiens	Q96QU6	Y2H Array	25416956
Intra	UQCRB	P14927	ACAP1	Homo sapiens	Q15027	Validated Y2H	32296183
Intra	UQCRB	P14927	BECN1	Homo sapiens	Q14457	Y2H Pooling	32814053
Intra	UQCRB	P14927	BECN1	Homo sapiens	Q14457	Validated Y2H	32814053
Intra	UQCRB	P14927	BECN1	Homo sapiens	Q14457	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

UQCRB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82613	Complex III Subunit 7 Antibody (YA2358)	WB, IHC-P, IP	Human, Rat
HY-P82613A	Complex III Subunit 7 Antibody (YA2358)(PBS only)	WB, IHC-P, IP	Human, Rat

Related Diseases

Diseases	Alias
Mitochondrial Complex Iii Deficiency, Nuclear Type 3	Mitochondrial Complex Iii Deficiency Nuclear Type 3 MC3DN3 Mitochondrial Complex Iii Deficiency, Nuclear 3
Mitochondrial Complex Iii Deficiency	Complex 3 Mitochondrial Respiratory Chain Deficiency Isolated Coq-Cytochrome C Reductase Deficiency Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Mitochondrial Complex Iii Deficiency, Nuclear Type 1	MC1DN3 Mitochondrial Complex Iii Deficiency Nuclear Type 1 MC3DN1 Mitochondrial Complex I Deficiency, Nuclear Type 3 Mitochondrial Complex 1 Deficiency, Nuclear Type 3 Nuclear Type Mitochondrial Complex I Deficiency 3 Renal Tubulopathy-Encephalopathy-Liver Failure Syndrome Mitochondrial Complex Iii Deficiency, Nuclear 1 Complex 3 Mitochondrial Respiratory Chain Deficiency Complex Iii Mitochondrial Respiratory Chain Deficiency Mitochondrial Complex Iii Deficiency, Nuclear, Type 1 ]
Isolated Complex Iii Deficiency	Isolated Coq-Cytochrome C Reductase Deficiency Isolated Coenzyme Q-Cytochrome C Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex Iii Deficiency Isolated Ubiquinone-Cytochrome C Reductase Deficiency
Gracile Syndrome	Finnish Lethal Neonatal Metabolic Syndrome Growth Retardation, Amino Aciduria, Cholestasis, Iron Overload, Lactic Acidosis, And Early Death Flnms Fellman Syndrome Fellman Disease Finnish Lactic Acidosis With Hepatic Hemosiderosis Growth Restriction-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome Growth Delay-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome Lactic Acidosis, Finnish, With Hepatic Hemosiderosis Growth Retardation, Aminoaciduria, Cholestasis, Iron Overload, Lactic Acidosis And Early Death GRACILE
Bjornstad Syndrome	BJS Pili Torti And Nerve Deafness Ptd Pili Torti-Deafness Syndrome Deafness-Pili Torti-Hypogonadism Syndrome Deafness And Pili Torti, Bjornstad Type Pili Torti-Sensorineural Hearing Loss Björnstad Syndrome Ptnd Hearing Loss-Pili Torti-Hypogonadism Syndrome Bjoernstad Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N15497	Terpestacin	Inhibitor	/	Unkown
HY-RS15498	UQCRB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20509	Uqcrb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22897	Uqcrq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27018	Uqcrb Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UQCRB	MGD	MGI:1914780
Rattus norvegicus	UQCRB	RGD	RGD:1311971
Bos taurus	UQCRB	VGNC	VGNC:36694
Macaca mulatta	UQCRB	VGNC	VGNC:84134
Others	UQCRB	NCBI