CYC1 - cytochrome c1 Gene

Also Known as UQCR4; MC3DN6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1537

About CYC1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,095,076-144,097,525 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 77.6), duodenum (RPKM 50.4) and 25 other tissues.

Summary

This gene encodes a subunit of the cytochrome bc1 complex, which plays an important role in the mitochondrial respiratory chain by transferring electrons from the Rieske iron-sulfur protein to cytochrome c. Mutations in this gene may cause mitochondrial complex III deficiency, nuclear type 6. [provided by RefSeq, Dec 2013]

CYC1 Products (1)

mRNA	Protein	Name
NM_001916.5	NP_001907.3	cytochrome c1, heme protein, mitochondrial precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYC1 Protein Structure

Cytochrom_C1

0
100
200
300
325 a.a.

Protein Preferred Names	Protein Names
cytochrome c1, heme protein, mitochondrial	complex III subunit 4

CYC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CYC1	P08574	PDCD2	Homo sapiens	Q16342	Validated Y2H	32814053
Intra	CYC1	P08574	PDCD2	Homo sapiens	Q16342	Y2H Array	32814053
Intra	CYC1	P08574	PDCD2	Homo sapiens	Q16342	Y2H Pooling	32814053
Intra	CYC1	P08574	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	CYC1	P08574	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	CYC1	P08574	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	CYC1	P08574	UQCRB	Homo sapiens	P14927	Anti Tag CoIP	28514442
Intra	CYC1	P08574	UQCRB	Homo sapiens	P14927	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

CYC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810227	cytochrome c1 Antibody (YA9571)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat

Related Diseases

Diseases	Alias
Mitochondrial Complex Iii Deficiency, Nuclear Type 6	Mitochondrial Complex Iii Deficiency Nuclear Type 6 MC3DN6 Mitochondrial Complex Iii Deficiency, Nuclear 6
Isolated Complex Iii Deficiency	Isolated Coq-Cytochrome C Reductase Deficiency Isolated Coenzyme Q-Cytochrome C Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex Iii Deficiency Isolated Ubiquinone-Cytochrome C Reductase Deficiency
Mitochondrial Complex Iii Deficiency	Complex 3 Mitochondrial Respiratory Chain Deficiency Isolated Coq-Cytochrome C Reductase Deficiency Ubiquinone-Cytochrome C Oxidoreductase Deficiency
Hyperglycemia
Combined Oxidative Phosphorylation Deficiency 3	Fatal Mitochondrial Disease Due To Combined Oxidative Phosphorylation Defect Type 3 COXPD3 Encephalomyopathy, Respiratory Failure, And Lactic Acidosis Concentric Cardiomyopathy, Hypotonia, And Lactic Acidosis Fatal Mitochondrial Disease Due To Coxpd3 Concentric Cardiomyopathy Hypotonia And Lactic Acidosis Encephalomyopathy Respiratory Failure And Lactic Acidosis Encephalomyopathy With Respiratory Failure And Lactic Acidosis Combined Oxidative Phosphorylation Deficiency, Type 3
Gracile Syndrome	Finnish Lethal Neonatal Metabolic Syndrome Growth Retardation, Amino Aciduria, Cholestasis, Iron Overload, Lactic Acidosis, And Early Death Flnms Fellman Syndrome Fellman Disease Finnish Lactic Acidosis With Hepatic Hemosiderosis Growth Restriction-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome Growth Delay-Aminoaciduria-Cholestasis-Iron Overload-Lactic Acidosis-Early Death Syndrome Lactic Acidosis, Finnish, With Hepatic Hemosiderosis Growth Retardation, Aminoaciduria, Cholestasis, Iron Overload, Lactic Acidosis And Early Death GRACILE
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Myoclonic Epilepsy Associated With Ragged-Red Fibers	Merrf Syndrome MERRF Fukuhara Syndrome Myoclonic Epilepsy Associated With Ragged Red Fibers Myoencephalopathy Ragged-Red Fiber Disease Myoclonic Epilepsy - Ragged Red Fibers Myoclonus Epilepsy And Ragged Red Fibers Myoclonus With Epilepsy And With Ragged Red Fibers Myoclonic Epilepsy With Ragged Red Fibers Myoclonic Epilepsy With Ragged-Red Fibers Fukuhara Disease Myoclonus Epilepsy Associated With Ragged-Red Fibres Myoclonus With Epilepsy With Ragged Red Fibers
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-147646	CDK1/Cyc B-IN-1		98.47%	Unkown
HY-RS03428	CYC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17636	Cyc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02133	CCNI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24096	Cyc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CYC1	VGNC	VGNC:50287
Felis catus	CYC1	VGNC	VGNC:61314
Bos taurus	CYC1	VGNC	VGNC:50266
Macaca mulatta	CYC1	VGNC	VGNC:71577
Mus musculus	CYC1	MGD	MGI:1913695
Rattus norvegicus	CYC1	RGD	RGD:1306597
Others	CYC1	NCBI