2. Gene
  3. PDCD2 - programmed cell death 2 Gene

PDCD2 - programmed cell death 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RP8; ZMYND7

Gene ID: 5134 | Gene type: protein coding

About PDCD2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,575,295-170,584,637 (from NCBI)

This gene has 15 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates Apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

PDCD2 Products(7)

mRNA Protein Name
NM_001199461.2 NP_001186390.1 programmed cell death protein 2 isoform 3
NM_001199462.2 NP_001186391.1 programmed cell death protein 2 isoform 4
NM_001199463.2 NP_001186392.1 programmed cell death protein 2 isoform 5
NM_001199464.2 NP_001186393.1 programmed cell death protein 2 isoform 6
NM_001363655.2 NP_001350584.1 programmed cell death protein 2 isoform 7
NM_002598.4 NP_002589.2 programmed cell death protein 2 isoform 1
NM_144781.3 NP_659005.1 programmed cell death protein 2 isoform 2

PDCD2 Protein Structure

zf-MYND

zf-MYND: MYND finger (135 - 172)

PDCD2_C

PDCD2_C: Programmed cell death protein 2, C-terminal putative domain (188 - 340)

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  • 344 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 2

zinc finger MYND domain-containing protein 7

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10191 PDCD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDCD2 MGD MGI:104643
Macaca mulatta PDCD2 VGNC VGNC:104419
Felis catus PDCD2 VGNC VGNC:97548
Rattus norvegicus PDCD2 RGD RGD:61887
Bos taurus PDCD2 VGNC VGNC:32660
Canis familiaris PDCD2 VGNC VGNC:44337