PDCD2 - programmed cell death 2 Gene

Also Known as RP8; ZMYND7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5134

About PDCD2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:170,575,295-170,584,637 (from NCBI)

This gene has 15 transcripts (splice variants), 195 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 7.8), thyroid (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a nuclear protein expressed in a variety of tissues. Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates Apoptosis by its effects on this protein. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 9 and 12. [provided by RefSeq, Dec 2010]

PDCD2 Products (7)

mRNA Protein Name
NM_001199461.2 NP_001186390.1 programmed cell death protein 2 isoform 3
NM_001199462.2 NP_001186391.1 programmed cell death protein 2 isoform 4
NM_001199463.2 NP_001186392.1 programmed cell death protein 2 isoform 5
NM_001199464.2 NP_001186393.1 programmed cell death protein 2 isoform 6
NM_001363655.2 NP_001350584.1 programmed cell death protein 2 isoform 7
NM_002598.4 NP_002589.2 programmed cell death protein 2 isoform 1
NM_144781.3 NP_659005.1 programmed cell death protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23382074 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19146857 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
20605493 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
20605493 GOA
involved in positive regulation of hematopoietic stem cell proliferation IMP
IMP: Inferred from mutant phenotype
22922207 GOA
involved in regulation of hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
22922207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD2 Protein Structure

zf-MYND

zf-MYND: MYND finger (135 - 172)

PDCD2_C

PDCD2_C: Programmed cell death protein 2, C-terminal putative domain (188 - 340)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

programmed cell death protein 2

  • zinc finger MYND domain-containing protein 7

PDCD2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDCD2 Q16342 TBC1D21 Homo sapiens Q8IYX1
Validated Y2H
32296183
Intra
PDCD2 Q16342 RPS2 Homo sapiens P15880
Anti Tag CoIP
33961781
Intra
PDCD2 Q16342 PRKN Homo sapiens O60260
Anti Tag CoIP
19146857
Intra
PDCD2 Q16342 PRKN Homo sapiens O60260
Y2H
19146857
Cross: Cross-species interaction Intra: Intraspecies interaction

PDCD2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81567 PDCD2 Antibody (YA1312) WB Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10191 PDCD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21684 Pdcd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28202 Pdcd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PDCD2 MGD MGI:104643
Macaca mulatta PDCD2 VGNC VGNC:104419
Felis catus PDCD2 VGNC VGNC:97548
Rattus norvegicus PDCD2 RGD RGD:61887
Bos taurus PDCD2 VGNC VGNC:32660
Canis familiaris PDCD2 VGNC VGNC:44337
Others PDCD2 NCBI