TBC1D21 - TBC1 domain family member 21 Gene
Also Known as MgcRabGAP
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 161514
Summary
Enables GTPase activator activity and small GTPase binding activity. Predicted to be involved in plasma membrane to endosome transport; sperm axoneme assembly; and sperm mitochondrial sheath assembly. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Restricted expression toward testis (RPKM 8.2).
TBC1D21 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001286434.2 | NP_001273363.1 | TBC1 domain family member 21 isoform 2 |
| NM_153356.3 | NP_699187.1 | TBC1 domain family member 21 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables GTPase activator activity |
IDA
IDA: Inferred from direct assay
|
28067790 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
28067790 | GOA |
| enables small GTPase binding |
IMP
IMP: Inferred from mutant phenotype
|
16923123 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| NOT involved in regulation of cilium assembly |
IMP
IMP: Inferred from mutant phenotype
|
17646400 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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TBC1D21 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
TBC1D21 | Q8IYX1 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT40 | Homo sapiens | Q6A162 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | NR1D2 | Homo sapiens | Q6NSM0 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | NR1D2 | Homo sapiens | Q6NSM0 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | RIBC1 | Homo sapiens | Q8N443 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT37 | Homo sapiens | O76014 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT37 | Homo sapiens | O76014 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT38 | Homo sapiens | O76015 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT35 | Homo sapiens | Q92764 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | REL | Homo sapiens | Q04864-2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SEPTIN2 | Homo sapiens | Q15019-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SEPTIN2 | Homo sapiens | Q15019-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | LCN2 | Homo sapiens | P80188 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | TCF12 | Homo sapiens | Q99081-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | TCF12 | Homo sapiens | Q99081-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | TCF12 | Homo sapiens | Q99081-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | RAB3IP | Homo sapiens | Q96QF0-7 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | RAB3IP | Homo sapiens | Q96QF0-7 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | RAB3IP | Homo sapiens | Q96QF0-7 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SAMD4A | Homo sapiens | Q9UPU9-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SAMD4A | Homo sapiens | Q9UPU9-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SAMD4A | Homo sapiens | Q9UPU9-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | TIMM10 | Homo sapiens | P62072 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | TIMM10 | Homo sapiens | P62072 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SNX7 | Homo sapiens | Q9UNH6-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SNX7 | Homo sapiens | Q9UNH6-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | SNX7 | Homo sapiens | Q9UNH6-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PMF1 | Homo sapiens | Q6P1K2-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PMF1 | Homo sapiens | Q6P1K2-3 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GAS2 | Homo sapiens | O43903-2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GAS2 | Homo sapiens | O43903-2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KIF26A | Homo sapiens | Q9ULI4 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KIF26A | Homo sapiens | Q9ULI4 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KIF26A | Homo sapiens | Q9ULI4 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | MEOX2 | Homo sapiens | Q6FHY5 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PDCD2 | Homo sapiens | Q16342 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PDCD2 | Homo sapiens | Q16342 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GTF2E1 | Homo sapiens | P29083 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GTF2E1 | Homo sapiens | P29083 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PMF1 | Homo sapiens | Q6P1K2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | PMF1 | Homo sapiens | Q6P1K2 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | STMN3 | Homo sapiens | Q9NZ72 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | STMN3 | Homo sapiens | Q9NZ72 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | STMN3 | Homo sapiens | Q9NZ72 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | KRT15 | Homo sapiens | P19012 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | CFAP53 | Homo sapiens | Q96M91 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | CFAP53 | Homo sapiens | Q96M91 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | CFAP53 | Homo sapiens | Q96M91 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GFAP | Homo sapiens | P14136 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | GFAP | Homo sapiens | P14136 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | EVI5L | Homo sapiens | Q96CN4 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | EVI5L | Homo sapiens | Q96CN4 | 32296183 | |
|
Intra
|
TBC1D21 | Q8IYX1 | EVI5L | Homo sapiens | Q96CN4 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction